Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary

In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incomplete...

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Autores principales: Li, Yun, Zhang, Qiao, Carreira-Rosario, Arnaldo, Maines, Jean Z., McKearin, Dennis M., Buszczak, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603962/
https://www.ncbi.nlm.nih.gov/pubmed/23526974
http://dx.doi.org/10.1371/journal.pone.0058301
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author Li, Yun
Zhang, Qiao
Carreira-Rosario, Arnaldo
Maines, Jean Z.
McKearin, Dennis M.
Buszczak, Michael
author_facet Li, Yun
Zhang, Qiao
Carreira-Rosario, Arnaldo
Maines, Jean Z.
McKearin, Dennis M.
Buszczak, Michael
author_sort Li, Yun
collection PubMed
description In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam.
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spelling pubmed-36039622013-03-22 Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary Li, Yun Zhang, Qiao Carreira-Rosario, Arnaldo Maines, Jean Z. McKearin, Dennis M. Buszczak, Michael PLoS One Research Article In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam. Public Library of Science 2013-03-20 /pmc/articles/PMC3603962/ /pubmed/23526974 http://dx.doi.org/10.1371/journal.pone.0058301 Text en © 2013 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Yun
Zhang, Qiao
Carreira-Rosario, Arnaldo
Maines, Jean Z.
McKearin, Dennis M.
Buszczak, Michael
Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
title Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
title_full Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
title_fullStr Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
title_full_unstemmed Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
title_short Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary
title_sort mei-p26 cooperates with bam, bgcn and sxl to promote early germline development in the drosophila ovary
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603962/
https://www.ncbi.nlm.nih.gov/pubmed/23526974
http://dx.doi.org/10.1371/journal.pone.0058301
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