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Inhibitors of Hedgehog Acyltransferase Block Sonic Hedgehog Signaling
Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a novel target for Shh pathway inhibition. A target-oriented high-throughput screen was used to ident...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604071/ https://www.ncbi.nlm.nih.gov/pubmed/23416332 http://dx.doi.org/10.1038/nchembio.1184 |