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Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated through distinct biochemical mechanisms
The transcription factor Bcl-6 orchestrates the germinal center reaction through its actions in B and T cells, and regulates inflammatory signaling in macrophages. We report that genetic replacement by mutant Bcl-6, which cannot bind corepressors to its BTB domain, disrupted germinal center formatio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604075/ https://www.ncbi.nlm.nih.gov/pubmed/23455674 http://dx.doi.org/10.1038/ni.2543 |