No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population

There is a huge variability of hepatic CYP3A4 level in human populations, which was believed to contribute to different responses to drugs among individuals. Transcription of CYP3A4 was regulated by transcription factors such as pregnane X receptor (PXR). MiRNA hsa-miR-148a was previously reported t...

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Autores principales: Wei, Zhiyun, Chen, Mingjie, Zhang, Yiting, Wang, Xiaofei, Jiang, Songshan, Wang, Yang, Wu, Xi, Qin, Shengying, He, Lin, Zhang, Lirong, Xing, Qinghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604168/
https://www.ncbi.nlm.nih.gov/pubmed/23527115
http://dx.doi.org/10.1371/journal.pone.0059141
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author Wei, Zhiyun
Chen, Mingjie
Zhang, Yiting
Wang, Xiaofei
Jiang, Songshan
Wang, Yang
Wu, Xi
Qin, Shengying
He, Lin
Zhang, Lirong
Xing, Qinghe
author_facet Wei, Zhiyun
Chen, Mingjie
Zhang, Yiting
Wang, Xiaofei
Jiang, Songshan
Wang, Yang
Wu, Xi
Qin, Shengying
He, Lin
Zhang, Lirong
Xing, Qinghe
author_sort Wei, Zhiyun
collection PubMed
description There is a huge variability of hepatic CYP3A4 level in human populations, which was believed to contribute to different responses to drugs among individuals. Transcription of CYP3A4 was regulated by transcription factors such as pregnane X receptor (PXR). MiRNA hsa-miR-148a was previously reported to influence PXR expression in HepG2 cells and in Japanese populations. In this study, we conducted a similar correlation study in Chinese Han population (N = 24). No significant correlation of hsa-miR-148a was found with PXR expression or CYP3A4 expression. Our results suggest that hsa-miR-148a does not play a major role in the regulation of PXR or CYP3A4 expression in human livers from Chinese Han population.
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spelling pubmed-36041682013-03-22 No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population Wei, Zhiyun Chen, Mingjie Zhang, Yiting Wang, Xiaofei Jiang, Songshan Wang, Yang Wu, Xi Qin, Shengying He, Lin Zhang, Lirong Xing, Qinghe PLoS One Research Article There is a huge variability of hepatic CYP3A4 level in human populations, which was believed to contribute to different responses to drugs among individuals. Transcription of CYP3A4 was regulated by transcription factors such as pregnane X receptor (PXR). MiRNA hsa-miR-148a was previously reported to influence PXR expression in HepG2 cells and in Japanese populations. In this study, we conducted a similar correlation study in Chinese Han population (N = 24). No significant correlation of hsa-miR-148a was found with PXR expression or CYP3A4 expression. Our results suggest that hsa-miR-148a does not play a major role in the regulation of PXR or CYP3A4 expression in human livers from Chinese Han population. Public Library of Science 2013-03-20 /pmc/articles/PMC3604168/ /pubmed/23527115 http://dx.doi.org/10.1371/journal.pone.0059141 Text en © 2013 Wei et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wei, Zhiyun
Chen, Mingjie
Zhang, Yiting
Wang, Xiaofei
Jiang, Songshan
Wang, Yang
Wu, Xi
Qin, Shengying
He, Lin
Zhang, Lirong
Xing, Qinghe
No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population
title No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population
title_full No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population
title_fullStr No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population
title_full_unstemmed No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population
title_short No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population
title_sort no correlation of hsa-mir-148a with expression of pxr or cyp3a4 in human livers from chinese han population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604168/
https://www.ncbi.nlm.nih.gov/pubmed/23527115
http://dx.doi.org/10.1371/journal.pone.0059141
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