Cargando…

Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs

PURPOSE: This study aimed to determine the effects of the long-term use of dehydroepiandrosterone sulfate (DHEAS) on rat prostates and testes as well as on serum testosterone and DHEAS levels. MATERIALS AND METHODS: Thirty male rats aged 4 to 5 months were studied. A DHEAS suspension of 5 mg/kg per...

Descripción completa

Detalles Bibliográficos
Autores principales: Sah, Cem, Aridogan, Ibrahim Atilla, Izol, Volkan, Erdogan, Seyda, Doran, Saban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604575/
https://www.ncbi.nlm.nih.gov/pubmed/23524493
http://dx.doi.org/10.4111/kju.2013.54.3.199
_version_ 1782263761303764992
author Sah, Cem
Aridogan, Ibrahim Atilla
Izol, Volkan
Erdogan, Seyda
Doran, Saban
author_facet Sah, Cem
Aridogan, Ibrahim Atilla
Izol, Volkan
Erdogan, Seyda
Doran, Saban
author_sort Sah, Cem
collection PubMed
description PURPOSE: This study aimed to determine the effects of the long-term use of dehydroepiandrosterone sulfate (DHEAS) on rat prostates and testes as well as on serum testosterone and DHEAS levels. MATERIALS AND METHODS: Thirty male rats aged 4 to 5 months were studied. A DHEAS suspension of 5 mg/kg per rat was administered orally to the 15 rats in the experimental group 5 times a week, whereas saline was administered concurrently to the 15 rats in the control group. Intracardiac blood samples were drawn to determine hormone levels, and histological samples of prostate and testes were evaluated under light microscopy. RESULTS: At the end of the 6-month study period, histological examinations performed on prostate preparations showed that the atrophy score of the experimental group was significantly lower than the scores of the sham and control groups (p<0.001 and p<0.001, respectively). The serum total testosterone and DHEAS levels of the rats in the study group were significantly increased (p<0.001). CONCLUSIONS: In our study, we determined that the long-term use of DHEAS does not have any detrimental effects on the prostate or the testis; on the contrary, it protects the prostate from atrophy, which is imperative for the continuation of fertility as well as for increasing serum testosterone and DHEAS levels.
format Online
Article
Text
id pubmed-3604575
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Korean Urological Association
record_format MEDLINE/PubMed
spelling pubmed-36045752013-03-22 Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs Sah, Cem Aridogan, Ibrahim Atilla Izol, Volkan Erdogan, Seyda Doran, Saban Korean J Urol Original Article PURPOSE: This study aimed to determine the effects of the long-term use of dehydroepiandrosterone sulfate (DHEAS) on rat prostates and testes as well as on serum testosterone and DHEAS levels. MATERIALS AND METHODS: Thirty male rats aged 4 to 5 months were studied. A DHEAS suspension of 5 mg/kg per rat was administered orally to the 15 rats in the experimental group 5 times a week, whereas saline was administered concurrently to the 15 rats in the control group. Intracardiac blood samples were drawn to determine hormone levels, and histological samples of prostate and testes were evaluated under light microscopy. RESULTS: At the end of the 6-month study period, histological examinations performed on prostate preparations showed that the atrophy score of the experimental group was significantly lower than the scores of the sham and control groups (p<0.001 and p<0.001, respectively). The serum total testosterone and DHEAS levels of the rats in the study group were significantly increased (p<0.001). CONCLUSIONS: In our study, we determined that the long-term use of DHEAS does not have any detrimental effects on the prostate or the testis; on the contrary, it protects the prostate from atrophy, which is imperative for the continuation of fertility as well as for increasing serum testosterone and DHEAS levels. The Korean Urological Association 2013-03 2013-03-15 /pmc/articles/PMC3604575/ /pubmed/23524493 http://dx.doi.org/10.4111/kju.2013.54.3.199 Text en © The Korean Urological Association, 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sah, Cem
Aridogan, Ibrahim Atilla
Izol, Volkan
Erdogan, Seyda
Doran, Saban
Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs
title Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs
title_full Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs
title_fullStr Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs
title_full_unstemmed Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs
title_short Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs
title_sort effects of long-term administration of the antiaging hormone dehydroepiandrosterone sulfate on rat prostates and testes as androgen-dependent organs
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604575/
https://www.ncbi.nlm.nih.gov/pubmed/23524493
http://dx.doi.org/10.4111/kju.2013.54.3.199
work_keys_str_mv AT sahcem effectsoflongtermadministrationoftheantiaginghormonedehydroepiandrosteronesulfateonratprostatesandtestesasandrogendependentorgans
AT aridoganibrahimatilla effectsoflongtermadministrationoftheantiaginghormonedehydroepiandrosteronesulfateonratprostatesandtestesasandrogendependentorgans
AT izolvolkan effectsoflongtermadministrationoftheantiaginghormonedehydroepiandrosteronesulfateonratprostatesandtestesasandrogendependentorgans
AT erdoganseyda effectsoflongtermadministrationoftheantiaginghormonedehydroepiandrosteronesulfateonratprostatesandtestesasandrogendependentorgans
AT doransaban effectsoflongtermadministrationoftheantiaginghormonedehydroepiandrosteronesulfateonratprostatesandtestesasandrogendependentorgans