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Progesterone supplementation in women with otherwise unexplained recurrent miscarriages
CONTEXT: Recurrent miscarriages, the loss of three or more consecutive intrauterine pregnancies before 20 weeks of gestation with the same partner, affect 1%–1.5% of the pregnant population. The inadequate secretion of progesterone in early pregnancy has been proposed as a cause of recurrent miscarr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604830/ https://www.ncbi.nlm.nih.gov/pubmed/23533097 http://dx.doi.org/10.4103/0974-1208.106335 |
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author | Hussain, Munawar El-Hakim, Samawal Cahill, David J |
author_facet | Hussain, Munawar El-Hakim, Samawal Cahill, David J |
author_sort | Hussain, Munawar |
collection | PubMed |
description | CONTEXT: Recurrent miscarriages, the loss of three or more consecutive intrauterine pregnancies before 20 weeks of gestation with the same partner, affect 1%–1.5% of the pregnant population. The inadequate secretion of progesterone in early pregnancy has been proposed as a cause of recurrent miscarriages. AIMS: The aim was to investigate the efficacy of progesterone supplementation in patients with unexplained recurrent miscarriages. SETTINGS AND DESIGN: This was a 9-year cohort study of women with otherwise unexplained recurrent miscarriages who attended a recurrent miscarriage clinic in a tertiary care university hospital. SUBJECTS AND METHODS: Women with at least three unexplained recurrent miscarriages were included in the study. They were divided into three groups according to their initial and 48-h repeat progesterone levels. For women with inadequate endogenous progesterone secretion, natural progesterone vaginal pessaries 400 mg 12-hourly were offered until 12 weeks gestation. STATISTICAL ANALYSIS: Proportions and 95% confidence intervals calculated for categorical variables and the chi-square test were used to show statistical significance. Medians and ranges were calculated for noncontinuous variables. RESULTS: Pregnancy cycles (n = 203) were analyzed to examine the miscarriage rate following progesterone supplementation. Overall live birth and miscarriage rates were 63% and 36%, respectively. When analyzed by the number of previous miscarriages there was a reduction in the miscarriage rate following progesterone supplementation in women with 4 previous miscarriages when compared with historical data. CONCLUSIONS: Progesterone supplementation may have beneficial effects in women with otherwise unexplained recurrent miscarriages. |
format | Online Article Text |
id | pubmed-3604830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36048302013-03-26 Progesterone supplementation in women with otherwise unexplained recurrent miscarriages Hussain, Munawar El-Hakim, Samawal Cahill, David J J Hum Reprod Sci Original Article CONTEXT: Recurrent miscarriages, the loss of three or more consecutive intrauterine pregnancies before 20 weeks of gestation with the same partner, affect 1%–1.5% of the pregnant population. The inadequate secretion of progesterone in early pregnancy has been proposed as a cause of recurrent miscarriages. AIMS: The aim was to investigate the efficacy of progesterone supplementation in patients with unexplained recurrent miscarriages. SETTINGS AND DESIGN: This was a 9-year cohort study of women with otherwise unexplained recurrent miscarriages who attended a recurrent miscarriage clinic in a tertiary care university hospital. SUBJECTS AND METHODS: Women with at least three unexplained recurrent miscarriages were included in the study. They were divided into three groups according to their initial and 48-h repeat progesterone levels. For women with inadequate endogenous progesterone secretion, natural progesterone vaginal pessaries 400 mg 12-hourly were offered until 12 weeks gestation. STATISTICAL ANALYSIS: Proportions and 95% confidence intervals calculated for categorical variables and the chi-square test were used to show statistical significance. Medians and ranges were calculated for noncontinuous variables. RESULTS: Pregnancy cycles (n = 203) were analyzed to examine the miscarriage rate following progesterone supplementation. Overall live birth and miscarriage rates were 63% and 36%, respectively. When analyzed by the number of previous miscarriages there was a reduction in the miscarriage rate following progesterone supplementation in women with 4 previous miscarriages when compared with historical data. CONCLUSIONS: Progesterone supplementation may have beneficial effects in women with otherwise unexplained recurrent miscarriages. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3604830/ /pubmed/23533097 http://dx.doi.org/10.4103/0974-1208.106335 Text en Copyright: © Journal of Human Reproductive Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hussain, Munawar El-Hakim, Samawal Cahill, David J Progesterone supplementation in women with otherwise unexplained recurrent miscarriages |
title | Progesterone supplementation in women with otherwise unexplained recurrent miscarriages |
title_full | Progesterone supplementation in women with otherwise unexplained recurrent miscarriages |
title_fullStr | Progesterone supplementation in women with otherwise unexplained recurrent miscarriages |
title_full_unstemmed | Progesterone supplementation in women with otherwise unexplained recurrent miscarriages |
title_short | Progesterone supplementation in women with otherwise unexplained recurrent miscarriages |
title_sort | progesterone supplementation in women with otherwise unexplained recurrent miscarriages |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604830/ https://www.ncbi.nlm.nih.gov/pubmed/23533097 http://dx.doi.org/10.4103/0974-1208.106335 |
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