Structural basis for the inhibition of Mycobacterium tuberculosis l,d-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Difficulty in the treatment of tuberculosis and growing drug resistance in Mycobacterium tuberculosis (Mtb) are a global health issue. Carbapenems inactivate l,d-transpeptidases; meropenem, when administered with clavulanate, showed in vivo activity against extensively drug-resistant Mtb strains. Ld...

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Detalles Bibliográficos
Autores principales: Kim, Hyoun Sook, Kim, Jieun, Im, Ha Na, Yoon, Ji Young, An, Doo Ri, Yoon, Hye Jin, Kim, Jin Young, Min, Hye Kyeoung, Kim, Soon-Jong, Lee, Jae Young, Han, Byung Woo, Suh, Se Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605043/
https://www.ncbi.nlm.nih.gov/pubmed/23519417
http://dx.doi.org/10.1107/S0907444912048998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605043/
https://www.ncbi.nlm.nih.gov/pubmed/23519417
http://dx.doi.org/10.1107/S0907444912048998

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