Systematic Prediction of Pharmacodynamic Drug-Drug Interactions through Protein-Protein-Interaction Network

Identifying drug-drug interactions (DDIs) is a major challenge in drug development. Previous attempts have established formal approaches for pharmacokinetic (PK) DDIs, but there is not a feasible solution for pharmacodynamic (PD) DDIs because the endpoint is often a serious adverse event rather than...

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Detalles Bibliográficos
Autores principales: Huang, Jialiang, Niu, Chaoqun, Green, Christopher D., Yang, Lun, Mei, Hongkang, Han, Jing-Dong J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605053/
https://www.ncbi.nlm.nih.gov/pubmed/23555229
http://dx.doi.org/10.1371/journal.pcbi.1002998

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