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Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study
BACKGROUND: Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Island, during which we constituted a prospective cohort of viremic patients (n =...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605278/ https://www.ncbi.nlm.nih.gov/pubmed/23556021 http://dx.doi.org/10.1371/journal.pntd.0002137 |
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author | Schilte, Clémentine Staikovsky, Frédérik Couderc, Thérèse Madec, Yoann Carpentier, Florence Kassab, Somar Albert, Matthew L. Lecuit, Marc Michault, Alain |
author_facet | Schilte, Clémentine Staikovsky, Frédérik Couderc, Thérèse Madec, Yoann Carpentier, Florence Kassab, Somar Albert, Matthew L. Lecuit, Marc Michault, Alain |
author_sort | Schilte, Clémentine |
collection | PubMed |
description | BACKGROUND: Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Island, during which we constituted a prospective cohort of viremic patients (n = 180) and defined the clinical and biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya. METHODOLOGY/PRINCIPAL FINDINGS: Patients were submitted to clinical investigations 4, 6, 14 and 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia and 20 patients without arthralgia were randomly selected from the cohort and consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse and recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) and highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years and the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia and permitted an estimation of the economic burden associated with arthralgia. CONCLUSIONS/SIGNIFICANCE: This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation. |
format | Online Article Text |
id | pubmed-3605278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36052782013-04-03 Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study Schilte, Clémentine Staikovsky, Frédérik Couderc, Thérèse Madec, Yoann Carpentier, Florence Kassab, Somar Albert, Matthew L. Lecuit, Marc Michault, Alain PLoS Negl Trop Dis Research Article BACKGROUND: Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Island, during which we constituted a prospective cohort of viremic patients (n = 180) and defined the clinical and biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya. METHODOLOGY/PRINCIPAL FINDINGS: Patients were submitted to clinical investigations 4, 6, 14 and 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia and 20 patients without arthralgia were randomly selected from the cohort and consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse and recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) and highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years and the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia and permitted an estimation of the economic burden associated with arthralgia. CONCLUSIONS/SIGNIFICANCE: This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation. Public Library of Science 2013-03-21 /pmc/articles/PMC3605278/ /pubmed/23556021 http://dx.doi.org/10.1371/journal.pntd.0002137 Text en © 2013 Schilte et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Schilte, Clémentine Staikovsky, Frédérik Couderc, Thérèse Madec, Yoann Carpentier, Florence Kassab, Somar Albert, Matthew L. Lecuit, Marc Michault, Alain Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study |
title | Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study |
title_full | Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study |
title_fullStr | Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study |
title_full_unstemmed | Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study |
title_short | Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study |
title_sort | chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605278/ https://www.ncbi.nlm.nih.gov/pubmed/23556021 http://dx.doi.org/10.1371/journal.pntd.0002137 |
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