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Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet

Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of thes...

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Autores principales: Xu, Jiqu, Zhou, Xiaoqi, Gao, Hui, Chen, Chang, Deng, Qianchun, Huang, Qingde, Ma, Jing, Wan, Zhengyang, Yang, Jin’e, Huang, Fenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605353/
https://www.ncbi.nlm.nih.gov/pubmed/23510587
http://dx.doi.org/10.1186/1476-511X-12-28
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author Xu, Jiqu
Zhou, Xiaoqi
Gao, Hui
Chen, Chang
Deng, Qianchun
Huang, Qingde
Ma, Jing
Wan, Zhengyang
Yang, Jin’e
Huang, Fenghong
author_facet Xu, Jiqu
Zhou, Xiaoqi
Gao, Hui
Chen, Chang
Deng, Qianchun
Huang, Qingde
Ma, Jing
Wan, Zhengyang
Yang, Jin’e
Huang, Fenghong
author_sort Xu, Jiqu
collection PubMed
description Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of these micronutrients are removed by the traditional refining process. The purpose of the present study was to determine whether rapeseed oil fortified with these micronutrients can decrease hepatic lipid accumulation and oxidative stress induced by high-fat diet. Sprague–Dawley rats received rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified RRO with low, middle and high quantities of these micronutrients for 10 weeks. Intake of RRO caused a remarkable hepatic steatosis. Micronutrients supplementation was effective in reducing steatosis as well as total triglyceride and total cholesterol contents in liver. These micronutrients also significantly increased hepatic antioxidant defense capacities, as evaluated by the significant elevation in the activities of SOD and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. These findings suggest that rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent fatty livers such as nonalcoholic fatty liver disease by ameliorating hepatic lipid accumulation and oxidative stress.
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spelling pubmed-36053532013-03-23 Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet Xu, Jiqu Zhou, Xiaoqi Gao, Hui Chen, Chang Deng, Qianchun Huang, Qingde Ma, Jing Wan, Zhengyang Yang, Jin’e Huang, Fenghong Lipids Health Dis Research Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of these micronutrients are removed by the traditional refining process. The purpose of the present study was to determine whether rapeseed oil fortified with these micronutrients can decrease hepatic lipid accumulation and oxidative stress induced by high-fat diet. Sprague–Dawley rats received rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified RRO with low, middle and high quantities of these micronutrients for 10 weeks. Intake of RRO caused a remarkable hepatic steatosis. Micronutrients supplementation was effective in reducing steatosis as well as total triglyceride and total cholesterol contents in liver. These micronutrients also significantly increased hepatic antioxidant defense capacities, as evaluated by the significant elevation in the activities of SOD and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. These findings suggest that rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent fatty livers such as nonalcoholic fatty liver disease by ameliorating hepatic lipid accumulation and oxidative stress. BioMed Central 2013-03-06 /pmc/articles/PMC3605353/ /pubmed/23510587 http://dx.doi.org/10.1186/1476-511X-12-28 Text en Copyright ©2013 Xu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Xu, Jiqu
Zhou, Xiaoqi
Gao, Hui
Chen, Chang
Deng, Qianchun
Huang, Qingde
Ma, Jing
Wan, Zhengyang
Yang, Jin’e
Huang, Fenghong
Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
title Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
title_full Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
title_fullStr Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
title_full_unstemmed Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
title_short Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
title_sort micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605353/
https://www.ncbi.nlm.nih.gov/pubmed/23510587
http://dx.doi.org/10.1186/1476-511X-12-28
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