RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

Talin activates integrins, couples them to F-actin, and recruits vinculin to focal adhesions (FAs). Here, we report the structural characterization of the talin rod: 13 helical bundles (R1–R13) organized into a compact cluster of four-helix bundles (R2–R4) within a linear chain of five-helix bundles...

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Detalles Bibliográficos
Autores principales: Goult, Benjamin T., Zacharchenko, Thomas, Bate, Neil, Tsang, Ricky, Hey, Fiona, Gingras, Alexandre R., Elliott, Paul R., Roberts, Gordon C. K., Ballestrem, Christoph, Critchley, David R., Barsukov, Igor L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605642/
https://www.ncbi.nlm.nih.gov/pubmed/23389036
http://dx.doi.org/10.1074/jbc.M112.438119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605642/
https://www.ncbi.nlm.nih.gov/pubmed/23389036
http://dx.doi.org/10.1074/jbc.M112.438119

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