Cargando…

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

Talin activates integrins, couples them to F-actin, and recruits vinculin to focal adhesions (FAs). Here, we report the structural characterization of the talin rod: 13 helical bundles (R1–R13) organized into a compact cluster of four-helix bundles (R2–R4) within a linear chain of five-helix bundles...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goult, Benjamin T., Zacharchenko, Thomas, Bate, Neil, Tsang, Ricky, Hey, Fiona, Gingras, Alexandre R., Elliott, Paul R., Roberts, Gordon C. K., Ballestrem, Christoph, Critchley, David R., Barsukov, Igor L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605642/ https://www.ncbi.nlm.nih.gov/pubmed/23389036 http://dx.doi.org/10.1074/jbc.M112.438119

Ejemplares similares

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin
por: Gingras, Alexandre R., et al.
Publicado: (2010)

The Structure of an Interdomain Complex That Regulates Talin Activity
por: Goult, Benjamin T., et al.
Publicado: (2009)

Vinculin controls talin engagement with the actomyosin machinery
por: Atherton, Paul, et al.
Publicado: (2015)

Structural Determinants of Integrin Binding to the Talin Rod
por: Gingras, Alexandre R., et al.
Publicado: (2009)

The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site
por: Goult, Benjamin T., et al.
Publicado: (2010)

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex
por: Zacharchenko, Thomas, et al.
Publicado: (2016)

Relief of talin autoinhibition triggers a force-independent association with vinculin
por: Atherton, Paul, et al.
Publicado: (2019)

Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
por: Vigouroux, Clémence, et al.
Publicado: (2020)

The structural basis of the talin–KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions
por: Li, Xingchen, et al.
Publicado: (2023)

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation
por: Yao, Mingxi, et al.
Publicado: (2014)

Chlamydial virulence factor TarP mimics talin to disrupt the talin‐vinculin complex
por: Whitewood, Austin J., et al.
Publicado: (2018)

Vinculins interaction with talin is essential for mammary epithelial differentiation
por: Wang, Pengbo, et al.
Publicado: (2019)

The structure of the C-terminal actin-binding domain of talin
por: Gingras, Alexandre R, et al.
Publicado: (2008)

Vinculin controls focal adhesion formation by direct interactions with talin and actin
por: Humphries, Jonathan D., et al.
Publicado: (2007)

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation
por: Goult, Benjamin T, et al.
Publicado: (2010)

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
por: Elliott, Paul R., et al.
Publicado: (2010)

Allosteric activation of vinculin by talin
por: Franz, Florian, et al.
Publicado: (2023)

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics
por: Bate, Neil, et al.
Publicado: (2012)

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion
por: Yang, Jun, et al.
Publicado: (2014)

Domain Motion in Cytochrome P450 Reductase: CONFORMATIONAL EQUILIBRIA REVEALED BY NMR AND SMALL-ANGLE X-RAY SCATTERING
por: Ellis, Jacqueline, et al.
Publicado: (2009)

Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation
por: Han, Sangyoon J, et al.
Publicado: (2021)

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin
por: Margadant, Felix, et al.
Publicado: (2011)

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration
por: Lagarrigue, Frederic, et al.
Publicado: (2015)

Identification of a talin binding site in the cytoskeletal protein vinculin
Publicado: (1989)

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors
por: Rienzo, Matthew, et al.
Publicado: (2016)

Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations
por: Meyer, Virginia, et al.
Publicado: (2016)

Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions
por: Atherton, Paul, et al.
Publicado: (2022)

Determinants of Small Ubiquitin-like Modifier 1 (SUMO1) Protein Specificity, E3 Ligase, and SUMO-RanGAP1 Binding Activities of Nucleoporin RanBP2
por: Gareau, Jaclyn R., et al.
Publicado: (2012)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain
por: Salvage, Samantha C., et al.
Publicado: (2019)

A Common β-Sheet Architecture Underlies in Vitro and in Vivo β(2)-Microglobulin Amyloid Fibrils
por: Jahn, Thomas R., et al.
Publicado: (2008)

Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions
por: Ortega-Roldan, Jose Luis, et al.
Publicado: (2013)

Amino Acid Region 1000–1008 of Factor V Is a Dynamic Regulator for the Emergence of Procoagulant Activity
por: Wiencek, Joesph R., et al.
Publicado: (2013)

Induced-fit Mechanism for Prolyl Endopeptidase
por: Li, Min, et al.
Publicado: (2010)

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
por: Tomar, Sakshi, et al.
Publicado: (2015)

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features
por: Karim, Md Fazlul, et al.
Publicado: (2020)

N-terminal Domain of Prion Protein Directs Its Oligomeric Association
por: Trevitt, Clare R., et al.
Publicado: (2014)

Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus
por: van Straaten, Karin E., et al.
Publicado: (2012)

Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains
por: Ma, Liang, et al.
Publicado: (2009)

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1
por: Kopp, Petra M., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_r4vq4epvv42n26lvml54d3c8rp