Cargando…

The missense variation landscape of FTO, MC4R and TMEM18 in obese children of African ancestry

Common variation at the loci harboring FTO, MC4R and TMEM18 is consistently reported as being statistically the most strongly associated with obesity. We investigated if these loci also harbor rarer missense variants that confer substantially higher risk of common childhood obesity in African Americ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deliard, Sandra, Panossian, Saarene, Mentch, Frank D., Kim, Cecilia E., Hou, Cuiping, Frackelton, Edward C., Bradfield, Jonathan P., Glessner, Joseph T., Zhang, Haitao, Wang, Kai, Sleiman, Patrick M.A., Chiavacci, Rosetta M., Berkowitz, Robert I., Hakonarson, Hakon, Zhao, Jianhua, Grant, Struan F.A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605748/ https://www.ncbi.nlm.nih.gov/pubmed/23505181 http://dx.doi.org/10.1002/oby.20147

Ejemplares similares

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP
por: Grant, Struan F. A., et al.
Publicado: (2008)

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature
por: Zhao, Jianhua, et al.
Publicado: (2010)

Association of the BANK 1 R61H variant with systemic lupus erythematosus in Americans of European and African ancestry
por: Grant, Struan FA, et al.
Publicado: (2009)

Examination of Type 2 Diabetes Loci Implicates CDKAL1 as a Birth Weight Gene
por: Zhao, Jianhua, et al.
Publicado: (2009)

Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI
por: Zhao, Jianhua, et al.
Publicado: (2010)

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci
por: Bradfield, Jonathan P., et al.
Publicado: (2011)

Duplication of the SLIT3 Locus on 5q35.1 Predisposes to Major Depressive Disorder
por: Glessner, Joseph T., et al.
Publicado: (2010)

From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes
por: Wei, Zhi, et al.
Publicado: (2009)

Assessing the functional consequence of loss of function variants using electronic medical record and large-scale genomics consortium efforts
por: Sleiman, Patrick, et al.
Publicado: (2014)

Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations
por: Li, Yun Rose, et al.
Publicado: (2020)

Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes
por: Qu, Hui-Qi, et al.
Publicado: (2008)

An electronic health record (EHR) phenotype algorithm to identify patients with attention deficit hyperactivity disorders (ADHD) and psychiatric comorbidities
por: Slaby, Isabella, et al.
Publicado: (2022)

Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan
por: Glessner, Joseph T., et al.
Publicado: (2013)

Mitochondrial DNA haplogroups and risk of attention deficit and hyperactivity disorder in European Americans
por: Chang, Xiao, et al.
Publicado: (2020)

Metabolomic profiling for dyslipidemia in pediatric patients with sickle cell disease, on behalf of the IHCC consortium
por: Qu, Hui-Qi, et al.
Publicado: (2022)

COVID-19 in pediatrics: Genetic susceptibility
por: Glessner, Joseph T., et al.
Publicado: (2022)

Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans
por: Qu, Hui-Qi, et al.
Publicado: (2022)

Gene Network Analysis in a Pediatric Cohort Identifies Novel Lung Function Genes
por: Ong, Bruce A., et al.
Publicado: (2013)

Rare Recurrent Variants in Noncoding Regions Impact Attention-Deficit Hyperactivity Disorder (ADHD) Gene Networks in Children of both African American and European American Ancestry
por: Liu, Yichuan, et al.
Publicado: (2021)

Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant
por: Desai, Akshatha, et al.
Publicado: (2016)

Burden of rare coding variants reveals genetic heterogeneity between obese and non-obese asthma patients in the African American population
por: Liu, Yichuan, et al.
Publicado: (2022)

Application of deep learning algorithm on whole genome sequencing data uncovers structural variants associated with multiple mental disorders in African American patients
por: Liu, Yichuan, et al.
Publicado: (2022)

Genome-wide association study reveals two loci for serum magnesium concentrations in European-American children
por: Chang, Xiao, et al.
Publicado: (2015)

Association of a rare NOTCH4 coding variant with systemic sclerosis: a family-based whole exome sequencing study
por: Cardinale, Christopher J., et al.
Publicado: (2016)

Common variants in polygenic schizophrenia
por: Glessner, Joseph T, et al.
Publicado: (2009)

Genetic Variation in Genes Encoding Airway Epithelial Potassium Channels Is Associated with Chronic Rhinosinusitis in a Pediatric Population
por: Purkey, Michael T., et al.
Publicado: (2014)

HIF-1α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions
por: Kelchtermans, Jelte, et al.
Publicado: (2021)

Large Copy-Number Variations Are Enriched in Cases With Moderate to Extreme Obesity
por: Wang, Kai, et al.
Publicado: (2010)

Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes
por: Grant, Struan F.A., et al.
Publicado: (2009)

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling
por: Li, Dong, et al.
Publicado: (2017)

Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling
por: Li, Dong, et al.
Publicado: (2017)

Circulating LIGHT (TNFSF14) and Interleukin-18 Levels in Sepsis-Induced Multi-Organ Injuries
por: Qu, Hui-Qi, et al.
Publicado: (2022)

Genome-Wide Association Study of Serum Minerals Levels in Children of Different Ethnic Background
por: Chang, Xiao, et al.
Publicado: (2015)

ParseCNV integrative copy number variation association software with quality tracking
por: Glessner, Joseph T., et al.
Publicado: (2013)

Missense variants in TMEM67 in a patient with Joubert syndrome
por: Huynh, Julie M., et al.
Publicado: (2018)

Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes
por: Almoguera, Berta, et al.
Publicado: (2014)

Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients
por: Qu, Jingchun, et al.
Publicado: (2021)

GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
por: Sleiman, Patrick, et al.
Publicado: (2013)

Expansion of Schizophrenia Gene Network Knowledge Using Machine Learning Selected Signals From Dorsolateral Prefrontal Cortex and Amygdala RNA-seq Data
por: Liu, Yichuan, et al.
Publicado: (2022)

Modeling genetic inheritance of copy number variations
por: Wang, Kai, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_n7o4omnj6e5fdh03lkdmd26jek