The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation

SNAREs provide energy and specificity to membrane fusion events. Fusogenic trans-SNARE complexes are assembled from Q-SNAREs embedded in one membrane and an R–SNARE embedded in the other. Regulation of membrane fusion events is crucial for intracellular trafficking. We identify the endosomal protein...

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Detalles Bibliográficos
Autores principales: Schäfer, Ingmar B., Hesketh, Geoffrey G., Bright, Nicholas A., Gray, Sally R., Pryor, Paul R., Evans, Philip R, Luzio, J. Paul, Owen, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605791/
https://www.ncbi.nlm.nih.gov/pubmed/23104059
http://dx.doi.org/10.1038/nsmb.2414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605791/
https://www.ncbi.nlm.nih.gov/pubmed/23104059
http://dx.doi.org/10.1038/nsmb.2414

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