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The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation

SNAREs provide energy and specificity to membrane fusion events. Fusogenic trans-SNARE complexes are assembled from Q-SNAREs embedded in one membrane and an R–SNARE embedded in the other. Regulation of membrane fusion events is crucial for intracellular trafficking. We identify the endosomal protein...

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Detalles Bibliográficos
Autores principales:	Schäfer, Ingmar B., Hesketh, Geoffrey G., Bright, Nicholas A., Gray, Sally R., Pryor, Paul R., Evans, Philip R, Luzio, J. Paul, Owen, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605791/ https://www.ncbi.nlm.nih.gov/pubmed/23104059 http://dx.doi.org/10.1038/nsmb.2414

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