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Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle
Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605902/ https://www.ncbi.nlm.nih.gov/pubmed/23554880 http://dx.doi.org/10.1371/journal.pone.0058245 |
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author | Amos, William Brooks-Pollock, Ellen Blackwell, Ruth Driscoll, Erin Nelson-Flower, Martha Conlan, Andrew J. K. |
author_facet | Amos, William Brooks-Pollock, Ellen Blackwell, Ruth Driscoll, Erin Nelson-Flower, Martha Conlan, Andrew J. K. |
author_sort | Amos, William |
collection | PubMed |
description | Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the test are classified as “reactors” and slaughtered. Recent studies have identified genetic markers associated with the reaction of cattle to the tuberculin test. At marker INRA111 a relatively common ‘22’ genotype occurs significantly more frequently in non-reactor cattle. Here we test the possibility that the putative protective ‘22’ genotype does not confer resistance but instead causes cattle that carry it to react less strongly to the prescribed test, and hence avoid slaughter, potentially even though they are infected. We show that, after controlling for age and breed, ‘22’ cattle react less strongly to the immunological challenge and may therefore be less likely to be classified as a reactor. These results highlight the potential discrepancy between infection and test status and imply that the effectiveness of the test-and-slaughter policy may be being compromised by selection for cattle that are genetically predisposed to react less strongly to tuberculin. |
format | Online Article Text |
id | pubmed-3605902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36059022013-04-02 Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle Amos, William Brooks-Pollock, Ellen Blackwell, Ruth Driscoll, Erin Nelson-Flower, Martha Conlan, Andrew J. K. PLoS One Research Article Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the test are classified as “reactors” and slaughtered. Recent studies have identified genetic markers associated with the reaction of cattle to the tuberculin test. At marker INRA111 a relatively common ‘22’ genotype occurs significantly more frequently in non-reactor cattle. Here we test the possibility that the putative protective ‘22’ genotype does not confer resistance but instead causes cattle that carry it to react less strongly to the prescribed test, and hence avoid slaughter, potentially even though they are infected. We show that, after controlling for age and breed, ‘22’ cattle react less strongly to the immunological challenge and may therefore be less likely to be classified as a reactor. These results highlight the potential discrepancy between infection and test status and imply that the effectiveness of the test-and-slaughter policy may be being compromised by selection for cattle that are genetically predisposed to react less strongly to tuberculin. Public Library of Science 2013-03-06 /pmc/articles/PMC3605902/ /pubmed/23554880 http://dx.doi.org/10.1371/journal.pone.0058245 Text en © 2013 Amos et al https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Amos, William Brooks-Pollock, Ellen Blackwell, Ruth Driscoll, Erin Nelson-Flower, Martha Conlan, Andrew J. K. Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle |
title | Genetic Predisposition to Pass the Standard SICCT Test for Bovine
Tuberculosis in British Cattle |
title_full | Genetic Predisposition to Pass the Standard SICCT Test for Bovine
Tuberculosis in British Cattle |
title_fullStr | Genetic Predisposition to Pass the Standard SICCT Test for Bovine
Tuberculosis in British Cattle |
title_full_unstemmed | Genetic Predisposition to Pass the Standard SICCT Test for Bovine
Tuberculosis in British Cattle |
title_short | Genetic Predisposition to Pass the Standard SICCT Test for Bovine
Tuberculosis in British Cattle |
title_sort | genetic predisposition to pass the standard sicct test for bovine
tuberculosis in british cattle |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605902/ https://www.ncbi.nlm.nih.gov/pubmed/23554880 http://dx.doi.org/10.1371/journal.pone.0058245 |
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