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Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle

Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the t...

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Autores principales: Amos, William, Brooks-Pollock, Ellen, Blackwell, Ruth, Driscoll, Erin, Nelson-Flower, Martha, Conlan, Andrew J. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605902/
https://www.ncbi.nlm.nih.gov/pubmed/23554880
http://dx.doi.org/10.1371/journal.pone.0058245
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author Amos, William
Brooks-Pollock, Ellen
Blackwell, Ruth
Driscoll, Erin
Nelson-Flower, Martha
Conlan, Andrew J. K.
author_facet Amos, William
Brooks-Pollock, Ellen
Blackwell, Ruth
Driscoll, Erin
Nelson-Flower, Martha
Conlan, Andrew J. K.
author_sort Amos, William
collection PubMed
description Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the test are classified as “reactors” and slaughtered. Recent studies have identified genetic markers associated with the reaction of cattle to the tuberculin test. At marker INRA111 a relatively common ‘22’ genotype occurs significantly more frequently in non-reactor cattle. Here we test the possibility that the putative protective ‘22’ genotype does not confer resistance but instead causes cattle that carry it to react less strongly to the prescribed test, and hence avoid slaughter, potentially even though they are infected. We show that, after controlling for age and breed, ‘22’ cattle react less strongly to the immunological challenge and may therefore be less likely to be classified as a reactor. These results highlight the potential discrepancy between infection and test status and imply that the effectiveness of the test-and-slaughter policy may be being compromised by selection for cattle that are genetically predisposed to react less strongly to tuberculin.
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spelling pubmed-36059022013-04-02 Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle Amos, William Brooks-Pollock, Ellen Blackwell, Ruth Driscoll, Erin Nelson-Flower, Martha Conlan, Andrew J. K. PLoS One Research Article Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the test are classified as “reactors” and slaughtered. Recent studies have identified genetic markers associated with the reaction of cattle to the tuberculin test. At marker INRA111 a relatively common ‘22’ genotype occurs significantly more frequently in non-reactor cattle. Here we test the possibility that the putative protective ‘22’ genotype does not confer resistance but instead causes cattle that carry it to react less strongly to the prescribed test, and hence avoid slaughter, potentially even though they are infected. We show that, after controlling for age and breed, ‘22’ cattle react less strongly to the immunological challenge and may therefore be less likely to be classified as a reactor. These results highlight the potential discrepancy between infection and test status and imply that the effectiveness of the test-and-slaughter policy may be being compromised by selection for cattle that are genetically predisposed to react less strongly to tuberculin. Public Library of Science 2013-03-06 /pmc/articles/PMC3605902/ /pubmed/23554880 http://dx.doi.org/10.1371/journal.pone.0058245 Text en © 2013 Amos et al https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Amos, William
Brooks-Pollock, Ellen
Blackwell, Ruth
Driscoll, Erin
Nelson-Flower, Martha
Conlan, Andrew J. K.
Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle
title Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle
title_full Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle
title_fullStr Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle
title_full_unstemmed Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle
title_short Genetic Predisposition to Pass the Standard SICCT Test for Bovine Tuberculosis in British Cattle
title_sort genetic predisposition to pass the standard sicct test for bovine tuberculosis in british cattle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605902/
https://www.ncbi.nlm.nih.gov/pubmed/23554880
http://dx.doi.org/10.1371/journal.pone.0058245
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