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Effect of blood protein concentrations on drug-dosing regimes: practical guidance
In this article the importance of blood proteins for drug dosing regimes is discussed. A simple mathematical model is presented for estimating recommended drug doses when the concentration of blood proteins is decreased. Practical guidance for drug dosing regimes is discussed and given in the form o...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606132/ https://www.ncbi.nlm.nih.gov/pubmed/23506635 http://dx.doi.org/10.1186/1742-4682-10-20 |
| _version_ | 1782263950819196928 |
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| author | Gurevich, Konstantin G |
| author_facet | Gurevich, Konstantin G |
| author_sort | Gurevich, Konstantin G |
| collection | PubMed |
| description | In this article the importance of blood proteins for drug dosing regimes is discussed. A simple mathematical model is presented for estimating recommended drug doses when the concentration of blood proteins is decreased. Practical guidance for drug dosing regimes is discussed and given in the form of a figure. It is demonstrated that correction of drug dosing regimes is needed only for when there is a high level of drug conjugation with blood proteins and a high degree of hypoalbuminaemia. An example of the use of this model is given. |
| format | Online Article Text |
| id | pubmed-3606132 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36061322013-03-27 Effect of blood protein concentrations on drug-dosing regimes: practical guidance Gurevich, Konstantin G Theor Biol Med Model Research In this article the importance of blood proteins for drug dosing regimes is discussed. A simple mathematical model is presented for estimating recommended drug doses when the concentration of blood proteins is decreased. Practical guidance for drug dosing regimes is discussed and given in the form of a figure. It is demonstrated that correction of drug dosing regimes is needed only for when there is a high level of drug conjugation with blood proteins and a high degree of hypoalbuminaemia. An example of the use of this model is given. BioMed Central 2013-03-18 /pmc/articles/PMC3606132/ /pubmed/23506635 http://dx.doi.org/10.1186/1742-4682-10-20 Text en Copyright ©2013 Gurevich; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Gurevich, Konstantin G Effect of blood protein concentrations on drug-dosing regimes: practical guidance |
| title | Effect of blood protein concentrations on drug-dosing regimes: practical guidance |
| title_full | Effect of blood protein concentrations on drug-dosing regimes: practical guidance |
| title_fullStr | Effect of blood protein concentrations on drug-dosing regimes: practical guidance |
| title_full_unstemmed | Effect of blood protein concentrations on drug-dosing regimes: practical guidance |
| title_short | Effect of blood protein concentrations on drug-dosing regimes: practical guidance |
| title_sort | effect of blood protein concentrations on drug-dosing regimes: practical guidance |
| topic | Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606132/ https://www.ncbi.nlm.nih.gov/pubmed/23506635 http://dx.doi.org/10.1186/1742-4682-10-20 |
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