HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in Adipocytes

BACKGROUND: HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available. However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular d...

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Detalles Bibliográficos
Autores principales: Zha, Beth S., Wan, Xiaoshan, Zhang, Xiaoxuan, Zha, Weibin, Zhou, Jun, Wabitsch, Martin, Wang, Guangji, Lyall, Vijay, Hylemon, Phillip B., Zhou, Huiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606318/
https://www.ncbi.nlm.nih.gov/pubmed/23533630
http://dx.doi.org/10.1371/journal.pone.0059514

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