Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

BACKGROUND: Adiponectin is able to induce NO-dependent vasodilation in Zucker lean (ZL) rats, but this effect is clearly alleviated in their diabetic littermates, the Zucker diabetic fatty (ZDF) rats. ZDF rats also exhibit hypoadiponectinemia and a suppressed expression of APPL1, an adaptor protein...

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Detalles Bibliográficos
Autores principales: Schmid, Peter M, Resch, Markus, Schach, Christian, Birner, Christoph, Riegger, Guenter A, Luchner, Andreas, Endemann, Dierk H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606629/
https://www.ncbi.nlm.nih.gov/pubmed/23497197
http://dx.doi.org/10.1186/1475-2840-12-46

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