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Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the s...

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Detalles Bibliográficos
Autores principales: Salmaso, Stefano, Caliceti, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606770/
https://www.ncbi.nlm.nih.gov/pubmed/23533769
http://dx.doi.org/10.1155/2013/374252
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author Salmaso, Stefano
Caliceti, Paolo
author_facet Salmaso, Stefano
Caliceti, Paolo
author_sort Salmaso, Stefano
collection PubMed
description Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the systemic side effects. By virtue of their small size they can be injected intravenously and disposed into the target tissues where they release the drug. Nanocarriers interact massively with the surrounding environment, namely, endothelium vessels as well as cells and blood proteins. Consequently, they are rapidly removed from the circulation mostly by the mononuclear phagocyte system. In order to endow nanosystems with long circulation properties, new technologies aimed at the surface modification of their physicochemical features have been developed. In particular, stealth nanocarriers can be obtained by polymeric coating. In this paper, the basic concept underlining the “stealth” properties of drug nanocarriers, the parameters influencing the polymer coating performance in terms of opsonins/macrophages interaction with the colloid surface, the most commonly used materials for the coating process and the outcomes of this peculiar procedure are thoroughly discussed.
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spelling pubmed-36067702013-03-26 Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers Salmaso, Stefano Caliceti, Paolo J Drug Deliv Review Article Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the systemic side effects. By virtue of their small size they can be injected intravenously and disposed into the target tissues where they release the drug. Nanocarriers interact massively with the surrounding environment, namely, endothelium vessels as well as cells and blood proteins. Consequently, they are rapidly removed from the circulation mostly by the mononuclear phagocyte system. In order to endow nanosystems with long circulation properties, new technologies aimed at the surface modification of their physicochemical features have been developed. In particular, stealth nanocarriers can be obtained by polymeric coating. In this paper, the basic concept underlining the “stealth” properties of drug nanocarriers, the parameters influencing the polymer coating performance in terms of opsonins/macrophages interaction with the colloid surface, the most commonly used materials for the coating process and the outcomes of this peculiar procedure are thoroughly discussed. Hindawi Publishing Corporation 2013 2013-03-07 /pmc/articles/PMC3606770/ /pubmed/23533769 http://dx.doi.org/10.1155/2013/374252 Text en Copyright © 2013 S. Salmaso and P. Caliceti. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Salmaso, Stefano
Caliceti, Paolo
Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
title Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
title_full Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
title_fullStr Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
title_full_unstemmed Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
title_short Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
title_sort stealth properties to improve therapeutic efficacy of drug nanocarriers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606770/
https://www.ncbi.nlm.nih.gov/pubmed/23533769
http://dx.doi.org/10.1155/2013/374252
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