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Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis

Background. Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes. Objective. To estimate the association between depression after stroke and subsequent mortality. Methods. A systematic search of articles using PubMed and Web of Science databas...

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Autores principales: Bartoli, Francesco, Lillia, Nicoletta, Lax, Annamaria, Crocamo, Cristina, Mantero, Vittorio, Carrà, Giuseppe, Agostoni, Elio, Clerici, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606772/
https://www.ncbi.nlm.nih.gov/pubmed/23533964
http://dx.doi.org/10.1155/2013/862978
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author Bartoli, Francesco
Lillia, Nicoletta
Lax, Annamaria
Crocamo, Cristina
Mantero, Vittorio
Carrà, Giuseppe
Agostoni, Elio
Clerici, Massimo
author_facet Bartoli, Francesco
Lillia, Nicoletta
Lax, Annamaria
Crocamo, Cristina
Mantero, Vittorio
Carrà, Giuseppe
Agostoni, Elio
Clerici, Massimo
author_sort Bartoli, Francesco
collection PubMed
description Background. Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes. Objective. To estimate the association between depression after stroke and subsequent mortality. Methods. A systematic search of articles using PubMed and Web of Science databases was performed. Odds ratios (ORs) and hazard ratios (HRs) were used as association measures for pooled analyses, based on random-effects models. Results. Thirteen studies, involving 59,598 subjects suffering from stroke (6,052 with and 53,546 without depression), had data suitable for meta-analysis. The pooled OR for mortality at followup in people suffering from depression after stroke was 1.22 (1.02–1.47). Subgroups analyses highlighted that only studies with medium-term followup (2–5 years) showed a statistically significant association between depression and risk of death. Four studies had data suitable for further analysis of pooled HR. The meta-analysis revealed a HR for mortality of 1.52 (1.02–2.26) among people with depression after stroke. Conclusions. Despite some limitations, this paper confirms the potential role of depression on post stroke mortality. The relationship between depression and mortality after stroke seems to be related to the followup duration. Further research is needed to clarify the nature of the association between depression after stroke and mortality.
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spelling pubmed-36067722013-03-26 Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis Bartoli, Francesco Lillia, Nicoletta Lax, Annamaria Crocamo, Cristina Mantero, Vittorio Carrà, Giuseppe Agostoni, Elio Clerici, Massimo Stroke Res Treat Review Article Background. Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes. Objective. To estimate the association between depression after stroke and subsequent mortality. Methods. A systematic search of articles using PubMed and Web of Science databases was performed. Odds ratios (ORs) and hazard ratios (HRs) were used as association measures for pooled analyses, based on random-effects models. Results. Thirteen studies, involving 59,598 subjects suffering from stroke (6,052 with and 53,546 without depression), had data suitable for meta-analysis. The pooled OR for mortality at followup in people suffering from depression after stroke was 1.22 (1.02–1.47). Subgroups analyses highlighted that only studies with medium-term followup (2–5 years) showed a statistically significant association between depression and risk of death. Four studies had data suitable for further analysis of pooled HR. The meta-analysis revealed a HR for mortality of 1.52 (1.02–2.26) among people with depression after stroke. Conclusions. Despite some limitations, this paper confirms the potential role of depression on post stroke mortality. The relationship between depression and mortality after stroke seems to be related to the followup duration. Further research is needed to clarify the nature of the association between depression after stroke and mortality. Hindawi Publishing Corporation 2013 2013-03-07 /pmc/articles/PMC3606772/ /pubmed/23533964 http://dx.doi.org/10.1155/2013/862978 Text en Copyright © 2013 Francesco Bartoli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bartoli, Francesco
Lillia, Nicoletta
Lax, Annamaria
Crocamo, Cristina
Mantero, Vittorio
Carrà, Giuseppe
Agostoni, Elio
Clerici, Massimo
Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis
title Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis
title_full Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis
title_fullStr Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis
title_full_unstemmed Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis
title_short Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis
title_sort depression after stroke and risk of mortality: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606772/
https://www.ncbi.nlm.nih.gov/pubmed/23533964
http://dx.doi.org/10.1155/2013/862978
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