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Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior
Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606797/ https://www.ncbi.nlm.nih.gov/pubmed/23533342 http://dx.doi.org/10.1155/2013/237260 |
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author | Coletti, Dario Berardi, Emanuele Aulino, Paola Rossi, Eleonora Moresi, Viviana Li, Zhenlin Adamo, Sergio |
author_facet | Coletti, Dario Berardi, Emanuele Aulino, Paola Rossi, Eleonora Moresi, Viviana Li, Zhenlin Adamo, Sergio |
author_sort | Coletti, Dario |
collection | PubMed |
description | Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation to substrains of the same inbred mouse strain, that is, BALB/c mice. We found that only a minority of the population of one of these substrains, the BALB/c J, performs spontaneous physical activity. In addition, the runners of this substrain cover a significantly smaller distance than the average runners of two other substrains, namely, the BALB/c ByJ and the BALB/c AnNCrl. The latter shows a striking level of voluntary activity, with the average distance run/day reaching up to about 12 kilometers. These runners are not outstanders, but they represent the majority of the population, with important scientific and economic fallouts to be taken into account during experimental planning. Spontaneous activity persists in pathological conditions, such as cancer-associated cachexia. This important amount of physical activity results in a minor muscle adaptation to endurance exercise over a three-week period; indeed, only a nonsignificant increase in NADH transferase+ fibers occurs in this time frame. |
format | Online Article Text |
id | pubmed-3606797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36067972013-03-26 Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior Coletti, Dario Berardi, Emanuele Aulino, Paola Rossi, Eleonora Moresi, Viviana Li, Zhenlin Adamo, Sergio ScientificWorldJournal Research Article Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation to substrains of the same inbred mouse strain, that is, BALB/c mice. We found that only a minority of the population of one of these substrains, the BALB/c J, performs spontaneous physical activity. In addition, the runners of this substrain cover a significantly smaller distance than the average runners of two other substrains, namely, the BALB/c ByJ and the BALB/c AnNCrl. The latter shows a striking level of voluntary activity, with the average distance run/day reaching up to about 12 kilometers. These runners are not outstanders, but they represent the majority of the population, with important scientific and economic fallouts to be taken into account during experimental planning. Spontaneous activity persists in pathological conditions, such as cancer-associated cachexia. This important amount of physical activity results in a minor muscle adaptation to endurance exercise over a three-week period; indeed, only a nonsignificant increase in NADH transferase+ fibers occurs in this time frame. Hindawi Publishing Corporation 2013-03-06 /pmc/articles/PMC3606797/ /pubmed/23533342 http://dx.doi.org/10.1155/2013/237260 Text en Copyright © 2013 Dario Coletti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Coletti, Dario Berardi, Emanuele Aulino, Paola Rossi, Eleonora Moresi, Viviana Li, Zhenlin Adamo, Sergio Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
title | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
title_full | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
title_fullStr | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
title_full_unstemmed | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
title_short | Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior |
title_sort | substrains of inbred mice differ in their physical activity as a behavior |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606797/ https://www.ncbi.nlm.nih.gov/pubmed/23533342 http://dx.doi.org/10.1155/2013/237260 |
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