Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers

The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is strongly influenced from the potential complications arising during the delicate phase of post-transplant immune restoration. The quantitative aspects of immune-cell repopulation after HSCT and the qualitative featu...

Descripción completa

Detalles Bibliográficos
Autores principales: Forcina, A., Noviello, M., Carbone, M. R., Bonini, Chiara, Bondanza, Attilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607069/
https://www.ncbi.nlm.nih.gov/pubmed/23531639
http://dx.doi.org/10.3389/fimmu.2013.00071
_version_ 1782264074835329024
author Forcina, A.
Noviello, M.
Carbone, M. R.
Bonini, Chiara
Bondanza, Attilio
author_facet Forcina, A.
Noviello, M.
Carbone, M. R.
Bonini, Chiara
Bondanza, Attilio
author_sort Forcina, A.
collection PubMed
description The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is strongly influenced from the potential complications arising during the delicate phase of post-transplant immune restoration. The quantitative aspects of immune-cell repopulation after HSCT and the qualitative features their functional restitution have been extensively reported. Nevertheless, measurable immune biomarkers predicting the clinical outcome of HSCT await formal validation. The aim of this review is an appraisal of most studies published so far on the predictive value of different T and NK-cell biomarkers after HSCT with emphasis on defined thresholds endorsed by multivariate analysis.
format Online
Article
Text
id pubmed-3607069
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36070692013-03-25 Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers Forcina, A. Noviello, M. Carbone, M. R. Bonini, Chiara Bondanza, Attilio Front Immunol Immunology The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is strongly influenced from the potential complications arising during the delicate phase of post-transplant immune restoration. The quantitative aspects of immune-cell repopulation after HSCT and the qualitative features their functional restitution have been extensively reported. Nevertheless, measurable immune biomarkers predicting the clinical outcome of HSCT await formal validation. The aim of this review is an appraisal of most studies published so far on the predictive value of different T and NK-cell biomarkers after HSCT with emphasis on defined thresholds endorsed by multivariate analysis. Frontiers Media S.A. 2013-03-25 /pmc/articles/PMC3607069/ /pubmed/23531639 http://dx.doi.org/10.3389/fimmu.2013.00071 Text en Copyright © 2013 Forcina, Noviello, Carbone, Bonini and Bondanza. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Forcina, A.
Noviello, M.
Carbone, M. R.
Bonini, Chiara
Bondanza, Attilio
Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers
title Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers
title_full Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers
title_fullStr Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers
title_full_unstemmed Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers
title_short Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers
title_sort predicting the clinical outcome of allogeneic hematopoietic stem cell transplantation: the long and winding road toward validated immune biomarkers
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607069/
https://www.ncbi.nlm.nih.gov/pubmed/23531639
http://dx.doi.org/10.3389/fimmu.2013.00071
work_keys_str_mv AT forcinaa predictingtheclinicaloutcomeofallogeneichematopoieticstemcelltransplantationthelongandwindingroadtowardvalidatedimmunebiomarkers
AT noviellom predictingtheclinicaloutcomeofallogeneichematopoieticstemcelltransplantationthelongandwindingroadtowardvalidatedimmunebiomarkers
AT carbonemr predictingtheclinicaloutcomeofallogeneichematopoieticstemcelltransplantationthelongandwindingroadtowardvalidatedimmunebiomarkers
AT boninichiara predictingtheclinicaloutcomeofallogeneichematopoieticstemcelltransplantationthelongandwindingroadtowardvalidatedimmunebiomarkers
AT bondanzaattilio predictingtheclinicaloutcomeofallogeneichematopoieticstemcelltransplantationthelongandwindingroadtowardvalidatedimmunebiomarkers

Ejemplares similares