Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis

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Sporadic and familiar amyotrophic lateral sclerosis (ALS) cases presented lower cholinergic activity than in healthy individuals in their still preserved spinal motoneurons (MNs) suggesting that cholinergic reduction might occur before MN death. To unravel how and when cholinergic function is compro...

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Detalles Bibliográficos
Autores principales: Casas, Caty, Herrando-Grabulosa, Mireia, Manzano, Raquel, Mancuso, Renzo, Osta, Rosario, Navarro, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607155/
https://www.ncbi.nlm.nih.gov/pubmed/23531559
http://dx.doi.org/10.1002/brb3.104

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