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Melatonin modulates baroreflex control via area postrema

Pineal gland and its hormone melatonin have been implicated in modulation of cardiovascular system. We aimed at studying the effects of melatonin on baroreflex sensitivity and the role of area postrema, as a component modulator of baroreflex arch. Mean arterial pressure (MAP) and heart rate (HR) wer...

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Autores principales: Campos, Luciana A, Cipolla-Neto, Jose, Michelini, Lisete C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607157/
https://www.ncbi.nlm.nih.gov/pubmed/23531786
http://dx.doi.org/10.1002/brb3.123
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author Campos, Luciana A
Cipolla-Neto, Jose
Michelini, Lisete C
author_facet Campos, Luciana A
Cipolla-Neto, Jose
Michelini, Lisete C
author_sort Campos, Luciana A
collection PubMed
description Pineal gland and its hormone melatonin have been implicated in modulation of cardiovascular system. We aimed at studying the effects of melatonin on baroreflex sensitivity and the role of area postrema, as a component modulator of baroreflex arch. Mean arterial pressure (MAP) and heart rate (HR) were recorded in conscious freely moving rats. Baroreceptor reflex sensitivity was assessed by determining the HR responses to ramped infusions of phenylephrine (PE) and sodium nitroprusside (SNP)-induced MAP changes. Melatonin bolus (0.11 mg/kg) immediately followed by its continuous infusion (0.43 × 10(−9) mol/L at a rate of 0.65 mL/h for 30 min) in healthy normotensive rats produced a downward shift of baroreceptor reflex control with a substantial inhibition of reflex tachycardia (−32%) and potentiation of reflex bradycardia (+20%). Ablation of area postrema (APX group) induced a sustained decrease of MAP (101 ± 3 vs. 116 ± 3 mmHg, P < 0.05 in comparison with sham rats, respectively). The melatonin-induced alterations of baroreflex function observed in the sham group were abolished in the APX group. We conclude that circulating melatonin can modulate baroreceptor reflex control of HR, thus resetting it toward lower HR values. The modulatory effects of melatonin may be mediated via melatonin receptors in the area postrema, located outside the blood–brain barrier.
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spelling pubmed-36071572013-03-25 Melatonin modulates baroreflex control via area postrema Campos, Luciana A Cipolla-Neto, Jose Michelini, Lisete C Brain Behav Original Research Pineal gland and its hormone melatonin have been implicated in modulation of cardiovascular system. We aimed at studying the effects of melatonin on baroreflex sensitivity and the role of area postrema, as a component modulator of baroreflex arch. Mean arterial pressure (MAP) and heart rate (HR) were recorded in conscious freely moving rats. Baroreceptor reflex sensitivity was assessed by determining the HR responses to ramped infusions of phenylephrine (PE) and sodium nitroprusside (SNP)-induced MAP changes. Melatonin bolus (0.11 mg/kg) immediately followed by its continuous infusion (0.43 × 10(−9) mol/L at a rate of 0.65 mL/h for 30 min) in healthy normotensive rats produced a downward shift of baroreceptor reflex control with a substantial inhibition of reflex tachycardia (−32%) and potentiation of reflex bradycardia (+20%). Ablation of area postrema (APX group) induced a sustained decrease of MAP (101 ± 3 vs. 116 ± 3 mmHg, P < 0.05 in comparison with sham rats, respectively). The melatonin-induced alterations of baroreflex function observed in the sham group were abolished in the APX group. We conclude that circulating melatonin can modulate baroreceptor reflex control of HR, thus resetting it toward lower HR values. The modulatory effects of melatonin may be mediated via melatonin receptors in the area postrema, located outside the blood–brain barrier. Blackwell Publishing Ltd 2013-03 2013-02-17 /pmc/articles/PMC3607157/ /pubmed/23531786 http://dx.doi.org/10.1002/brb3.123 Text en © 2013 Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Research
Campos, Luciana A
Cipolla-Neto, Jose
Michelini, Lisete C
Melatonin modulates baroreflex control via area postrema
title Melatonin modulates baroreflex control via area postrema
title_full Melatonin modulates baroreflex control via area postrema
title_fullStr Melatonin modulates baroreflex control via area postrema
title_full_unstemmed Melatonin modulates baroreflex control via area postrema
title_short Melatonin modulates baroreflex control via area postrema
title_sort melatonin modulates baroreflex control via area postrema
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607157/
https://www.ncbi.nlm.nih.gov/pubmed/23531786
http://dx.doi.org/10.1002/brb3.123
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