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Alteration of proteoglycan sulfation affects bone growth and remodeling

Diastrophic dysplasia (DTD) is a chondrodysplasia caused by mutations in the SLC26A2 gene, leading to reduced intracellular sulfate pool in chondrocytes, osteoblasts and fibroblasts. Hence, proteoglycans are undersulfated in the cartilage and bone of DTD patients. To characterize the bone phenotype...

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Detalles Bibliográficos
Autores principales:	Gualeni, Benedetta, de Vernejoul, Marie-Christine, Marty-Morieux, Caroline, De Leonardis, Fabio, Franchi, Marco, Monti, Luca, Forlino, Antonella, Houillier, Pascal, Rossi, Antonio, Geoffroy, Valerie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2013
Materias:	Original Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607217/ https://www.ncbi.nlm.nih.gov/pubmed/23369989 http://dx.doi.org/10.1016/j.bone.2013.01.036

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