Preparation, characterization, and in vitro and in vivo investigation of chitosan-coated poly (d,l-lactide-co-glycolide) nanoparticles for intestinal delivery of exendin-4

BACKGROUND: Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide) (CS-PLGA) nanoparticles was investigated for intestinal d...

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Detalles Bibliográficos
Autores principales: Wang, Mengshu, Zhang, Yong, Feng, Jiao, Gu, Tiejun, Dong, Qingguang, Yang, Xu, Sun, Yanan, Wu, Yongge, Chen, Yan, Kong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607418/
https://www.ncbi.nlm.nih.gov/pubmed/23658482
http://dx.doi.org/10.2147/IJN.S41457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607418/
https://www.ncbi.nlm.nih.gov/pubmed/23658482
http://dx.doi.org/10.2147/IJN.S41457

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