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Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population

AIMS: We aimed to replicate the association of the rs290487 (IVS3C/T) and rs7903146 (IVS3C/T) polymorphisms of transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Han Chinese people in Henan province, China. METHODS: In all, 1,842 patients with T2DM and 7,777 normal glucose...

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Autores principales: Wang, Jinjin, Li, Linlin, Zhang, Jiatong, Xie, Jing, Luo, Xinping, Yu, Dahai, Zhao, Jingzhi, Feng, Tianping, Pang, Chao, Yin, Lei, Hu, Fulan, Zhang, Jianfeng, Wang, Yan, Wang, Qian, Zhai, Yujia, You, Haifei, Zhu, Tian, Hu, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607568/
https://www.ncbi.nlm.nih.gov/pubmed/23536853
http://dx.doi.org/10.1371/journal.pone.0059053
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author Wang, Jinjin
Li, Linlin
Zhang, Jiatong
Xie, Jing
Luo, Xinping
Yu, Dahai
Zhao, Jingzhi
Feng, Tianping
Pang, Chao
Yin, Lei
Hu, Fulan
Zhang, Jianfeng
Wang, Yan
Wang, Qian
Zhai, Yujia
You, Haifei
Zhu, Tian
Hu, Dongsheng
author_facet Wang, Jinjin
Li, Linlin
Zhang, Jiatong
Xie, Jing
Luo, Xinping
Yu, Dahai
Zhao, Jingzhi
Feng, Tianping
Pang, Chao
Yin, Lei
Hu, Fulan
Zhang, Jianfeng
Wang, Yan
Wang, Qian
Zhai, Yujia
You, Haifei
Zhu, Tian
Hu, Dongsheng
author_sort Wang, Jinjin
collection PubMed
description AIMS: We aimed to replicate the association of the rs290487 (IVS3C/T) and rs7903146 (IVS3C/T) polymorphisms of transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Han Chinese people in Henan province, China. METHODS: In all, 1,842 patients with T2DM and 7,777 normal glucose-tolerant controls underwent genotyping for the T2DM-associated variants rs7903146 (IVS3C/T) and rs290487 (IVS3C/T). W performed a meta-analysis of the association of the risk alleles of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 and T2DM in Han Chinese by combining previous studies with the present study. RESULTS: We found that T2DM was associated with the CC genotype (1.364, 1.137–1.636, p  = 0.001), the recessive model (1.457, 1.156–1.838, p  = 0.001) of rs290487 (IVS3C/T) and haplotype CC (1.116, 1.034–1.204, p  = 0.004) in Han Chinese. Moreover, our meta-analyses supported the association of the T allele (IVS3C/T) of rs7903146 (1.36, 1.24–1.48; p  = 6.404×10(−12)) and T2DM but not the C allele of rs290487 (IVS3C/T) (0.99, 0.85–1.15, p  = 0.890) in Han Chinese. We found no interactions between behavioral risk factors (smoking, alcohol drinking, and physical activity) and rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms. CONCLUSIONS: The CC genotype and the recessive model of the variant rs290487 (IVS3C/T) and CC haplotype of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 may be associated with T2DM in Han Chinese people in Henan province, China.
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spelling pubmed-36075682013-03-27 Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population Wang, Jinjin Li, Linlin Zhang, Jiatong Xie, Jing Luo, Xinping Yu, Dahai Zhao, Jingzhi Feng, Tianping Pang, Chao Yin, Lei Hu, Fulan Zhang, Jianfeng Wang, Yan Wang, Qian Zhai, Yujia You, Haifei Zhu, Tian Hu, Dongsheng PLoS One Research Article AIMS: We aimed to replicate the association of the rs290487 (IVS3C/T) and rs7903146 (IVS3C/T) polymorphisms of transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Han Chinese people in Henan province, China. METHODS: In all, 1,842 patients with T2DM and 7,777 normal glucose-tolerant controls underwent genotyping for the T2DM-associated variants rs7903146 (IVS3C/T) and rs290487 (IVS3C/T). W performed a meta-analysis of the association of the risk alleles of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 and T2DM in Han Chinese by combining previous studies with the present study. RESULTS: We found that T2DM was associated with the CC genotype (1.364, 1.137–1.636, p  = 0.001), the recessive model (1.457, 1.156–1.838, p  = 0.001) of rs290487 (IVS3C/T) and haplotype CC (1.116, 1.034–1.204, p  = 0.004) in Han Chinese. Moreover, our meta-analyses supported the association of the T allele (IVS3C/T) of rs7903146 (1.36, 1.24–1.48; p  = 6.404×10(−12)) and T2DM but not the C allele of rs290487 (IVS3C/T) (0.99, 0.85–1.15, p  = 0.890) in Han Chinese. We found no interactions between behavioral risk factors (smoking, alcohol drinking, and physical activity) and rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms. CONCLUSIONS: The CC genotype and the recessive model of the variant rs290487 (IVS3C/T) and CC haplotype of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 may be associated with T2DM in Han Chinese people in Henan province, China. Public Library of Science 2013-03-25 /pmc/articles/PMC3607568/ /pubmed/23536853 http://dx.doi.org/10.1371/journal.pone.0059053 Text en © 2013 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Jinjin
Li, Linlin
Zhang, Jiatong
Xie, Jing
Luo, Xinping
Yu, Dahai
Zhao, Jingzhi
Feng, Tianping
Pang, Chao
Yin, Lei
Hu, Fulan
Zhang, Jianfeng
Wang, Yan
Wang, Qian
Zhai, Yujia
You, Haifei
Zhu, Tian
Hu, Dongsheng
Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
title Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
title_full Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
title_fullStr Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
title_full_unstemmed Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
title_short Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
title_sort association of rs7903146 (ivs3c/t) and rs290487 (ivs3c/t) polymorphisms in tcf7l2 with type 2 diabetes in 9,619 han chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607568/
https://www.ncbi.nlm.nih.gov/pubmed/23536853
http://dx.doi.org/10.1371/journal.pone.0059053
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