Cargando…

Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia

Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in local cortical networks. However, the cont...

Descripción completa

Detalles Bibliográficos
Autores principales: Grützner, Christine, Wibral, Michael, Sun, Limin, Rivolta, Davide, Singer, Wolf, Maurer, Konrad, Uhlhaas, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607810/
https://www.ncbi.nlm.nih.gov/pubmed/23532620
http://dx.doi.org/10.3389/fnhum.2013.00088
_version_ 1782264145795612672
author Grützner, Christine
Wibral, Michael
Sun, Limin
Rivolta, Davide
Singer, Wolf
Maurer, Konrad
Uhlhaas, Peter J.
author_facet Grützner, Christine
Wibral, Michael
Sun, Limin
Rivolta, Davide
Singer, Wolf
Maurer, Konrad
Uhlhaas, Peter J.
author_sort Grützner, Christine
collection PubMed
description Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in local cortical networks. However, the contribution of high gamma (>60 Hz) oscillations toward the pathophysiology is less established. To address this issue, we recorded magnetoencephalographic (MEG) data from 16 medicated patients with chronic schizophrenia and 16 controls during the perception of Mooney faces. MEG data were analysed in the 25–150 Hz frequency range. Patients showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces while responses to inverted stimuli were intact. Impaired processing of Mooney faces in schizophrenia patients was accompanied by a pronounced reduction in spectral power between 60–120 Hz (effect size: d = 1.26) which was correlated with disorganized symptoms (r = −0.72). Our findings demonstrate that deficits in high gamma-band oscillations as measured by MEG are a sensitive marker for aberrant cortical functioning in schizophrenia, suggesting an important aspect of the pathophysiology of the disorder.
format Online
Article
Text
id pubmed-3607810
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36078102013-03-26 Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia Grützner, Christine Wibral, Michael Sun, Limin Rivolta, Davide Singer, Wolf Maurer, Konrad Uhlhaas, Peter J. Front Hum Neurosci Neuroscience Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in local cortical networks. However, the contribution of high gamma (>60 Hz) oscillations toward the pathophysiology is less established. To address this issue, we recorded magnetoencephalographic (MEG) data from 16 medicated patients with chronic schizophrenia and 16 controls during the perception of Mooney faces. MEG data were analysed in the 25–150 Hz frequency range. Patients showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces while responses to inverted stimuli were intact. Impaired processing of Mooney faces in schizophrenia patients was accompanied by a pronounced reduction in spectral power between 60–120 Hz (effect size: d = 1.26) which was correlated with disorganized symptoms (r = −0.72). Our findings demonstrate that deficits in high gamma-band oscillations as measured by MEG are a sensitive marker for aberrant cortical functioning in schizophrenia, suggesting an important aspect of the pathophysiology of the disorder. Frontiers Media S.A. 2013-03-26 /pmc/articles/PMC3607810/ /pubmed/23532620 http://dx.doi.org/10.3389/fnhum.2013.00088 Text en Copyright © 2013 Grützner, Wibral, Sun, Rivolta, Singer, Maurer and Uhlhaas. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Grützner, Christine
Wibral, Michael
Sun, Limin
Rivolta, Davide
Singer, Wolf
Maurer, Konrad
Uhlhaas, Peter J.
Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
title Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
title_full Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
title_fullStr Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
title_full_unstemmed Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
title_short Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
title_sort deficits in high- (>60 hz) gamma-band oscillations during visual processing in schizophrenia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607810/
https://www.ncbi.nlm.nih.gov/pubmed/23532620
http://dx.doi.org/10.3389/fnhum.2013.00088
work_keys_str_mv AT grutznerchristine deficitsinhigh60hzgammabandoscillationsduringvisualprocessinginschizophrenia
AT wibralmichael deficitsinhigh60hzgammabandoscillationsduringvisualprocessinginschizophrenia
AT sunlimin deficitsinhigh60hzgammabandoscillationsduringvisualprocessinginschizophrenia
AT rivoltadavide deficitsinhigh60hzgammabandoscillationsduringvisualprocessinginschizophrenia
AT singerwolf deficitsinhigh60hzgammabandoscillationsduringvisualprocessinginschizophrenia
AT maurerkonrad deficitsinhigh60hzgammabandoscillationsduringvisualprocessinginschizophrenia
AT uhlhaaspeterj deficitsinhigh60hzgammabandoscillationsduringvisualprocessinginschizophrenia