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Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder
Major depressive disorder (MDD) is a long-term, recurrent condition that often takes a chronic course. It seems imperative that research should be focused on gaining a better understanding of what predicts recurrent MDD. As a major mediator of the stress response, corticotropin-releasing-hormone rec...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607833/ https://www.ncbi.nlm.nih.gov/pubmed/23529111 http://dx.doi.org/10.1038/srep01548 |
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author | Liu, Zhongchun Liu, Wanhong Yao, Lihua Yang, Can Xiao, Ling Wan, Qirong Gao, Kai Wang, Huiling Zhu, Fan Wang, Gaohua Xiao, Zheman |
author_facet | Liu, Zhongchun Liu, Wanhong Yao, Lihua Yang, Can Xiao, Ling Wan, Qirong Gao, Kai Wang, Huiling Zhu, Fan Wang, Gaohua Xiao, Zheman |
author_sort | Liu, Zhongchun |
collection | PubMed |
description | Major depressive disorder (MDD) is a long-term, recurrent condition that often takes a chronic course. It seems imperative that research should be focused on gaining a better understanding of what predicts recurrent MDD. As a major mediator of the stress response, corticotropin-releasing-hormone receptor 1 (CRHR1) has been demonstrated to be an important contributor to the pathogenesis of MDD. In this study, we show a significant increase in the G-allele (rs242939) of the CRHR1 gene in the recurrent MDD group compared with the control group, and an overrepresentation of G-G-T hyplotype of the CRHR1 gene in recurrent MDD. We also demonstrate the interaction of the CRHR1 gene and negative life events in recurrent MDD. These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. |
format | Online Article Text |
id | pubmed-3607833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36078332013-04-04 Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder Liu, Zhongchun Liu, Wanhong Yao, Lihua Yang, Can Xiao, Ling Wan, Qirong Gao, Kai Wang, Huiling Zhu, Fan Wang, Gaohua Xiao, Zheman Sci Rep Article Major depressive disorder (MDD) is a long-term, recurrent condition that often takes a chronic course. It seems imperative that research should be focused on gaining a better understanding of what predicts recurrent MDD. As a major mediator of the stress response, corticotropin-releasing-hormone receptor 1 (CRHR1) has been demonstrated to be an important contributor to the pathogenesis of MDD. In this study, we show a significant increase in the G-allele (rs242939) of the CRHR1 gene in the recurrent MDD group compared with the control group, and an overrepresentation of G-G-T hyplotype of the CRHR1 gene in recurrent MDD. We also demonstrate the interaction of the CRHR1 gene and negative life events in recurrent MDD. These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. Nature Publishing Group 2013-03-26 /pmc/articles/PMC3607833/ /pubmed/23529111 http://dx.doi.org/10.1038/srep01548 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Liu, Zhongchun Liu, Wanhong Yao, Lihua Yang, Can Xiao, Ling Wan, Qirong Gao, Kai Wang, Huiling Zhu, Fan Wang, Gaohua Xiao, Zheman Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder |
title | Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder |
title_full | Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder |
title_fullStr | Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder |
title_full_unstemmed | Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder |
title_short | Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder |
title_sort | negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607833/ https://www.ncbi.nlm.nih.gov/pubmed/23529111 http://dx.doi.org/10.1038/srep01548 |
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