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Laxative effects of Salecan on normal and two models of experimental constipated mice
BACKGROUND: Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intest...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607894/ https://www.ncbi.nlm.nih.gov/pubmed/23514598 http://dx.doi.org/10.1186/1471-230X-13-52 |
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author | Zhou, Mengyi Jia, Ping Chen, Jinping Xiu, Aihui Zhao, Yue Zhan, Yibei Chen, Peng Zhang, Jianfa |
author_facet | Zhou, Mengyi Jia, Ping Chen, Jinping Xiu, Aihui Zhao, Yue Zhan, Yibei Chen, Peng Zhang, Jianfa |
author_sort | Zhou, Mengyi |
collection | PubMed |
description | BACKGROUND: Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intestinal transit in normal and two models of drug-induced constipation mice. METHODS: ICR mice were administrated intragastrically (i.g.) by gavage with 100, 200 and 300 mg/kg body weight (BW) of Salecan while the control mice were received saline. The constipated mice were induced by two types of drugs, loperamide (5 mg/kg BW, i.g.) and clonidine (200 μg/kg BW, i.g.), after Salecan treatment while the control mice were received saline. Number, weight and water content of feces were subsequently measured. Small intestinal transit was monitored by phenol red marker meal. RESULTS: Salecan (300 mg/kg BW) significantly increased the number and weight of feces in normal mice. In two models of drug-induced constipation, Salecan dose-dependently restored the fecal number and fecal weight. The water content of feces was markedly affected by loperamide, but not by clonidine. Treatment with Salecan significantly raised the fecal water content in loperamide-induced constipation mice. Moreover, Salecan markedly stimulated the small intestinal transit in both loperamide- and clonidine-induced constipation model mice. CONCLUSIONS: These results suggest that Salecan has a potential to be used as a hydrophilic laxative for constipation. |
format | Online Article Text |
id | pubmed-3607894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36078942013-03-27 Laxative effects of Salecan on normal and two models of experimental constipated mice Zhou, Mengyi Jia, Ping Chen, Jinping Xiu, Aihui Zhao, Yue Zhan, Yibei Chen, Peng Zhang, Jianfa BMC Gastroenterol Research Article BACKGROUND: Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intestinal transit in normal and two models of drug-induced constipation mice. METHODS: ICR mice were administrated intragastrically (i.g.) by gavage with 100, 200 and 300 mg/kg body weight (BW) of Salecan while the control mice were received saline. The constipated mice were induced by two types of drugs, loperamide (5 mg/kg BW, i.g.) and clonidine (200 μg/kg BW, i.g.), after Salecan treatment while the control mice were received saline. Number, weight and water content of feces were subsequently measured. Small intestinal transit was monitored by phenol red marker meal. RESULTS: Salecan (300 mg/kg BW) significantly increased the number and weight of feces in normal mice. In two models of drug-induced constipation, Salecan dose-dependently restored the fecal number and fecal weight. The water content of feces was markedly affected by loperamide, but not by clonidine. Treatment with Salecan significantly raised the fecal water content in loperamide-induced constipation mice. Moreover, Salecan markedly stimulated the small intestinal transit in both loperamide- and clonidine-induced constipation model mice. CONCLUSIONS: These results suggest that Salecan has a potential to be used as a hydrophilic laxative for constipation. BioMed Central 2013-03-20 /pmc/articles/PMC3607894/ /pubmed/23514598 http://dx.doi.org/10.1186/1471-230X-13-52 Text en Copyright ©2013 Zhou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Mengyi Jia, Ping Chen, Jinping Xiu, Aihui Zhao, Yue Zhan, Yibei Chen, Peng Zhang, Jianfa Laxative effects of Salecan on normal and two models of experimental constipated mice |
title | Laxative effects of Salecan on normal and two models of experimental constipated mice |
title_full | Laxative effects of Salecan on normal and two models of experimental constipated mice |
title_fullStr | Laxative effects of Salecan on normal and two models of experimental constipated mice |
title_full_unstemmed | Laxative effects of Salecan on normal and two models of experimental constipated mice |
title_short | Laxative effects of Salecan on normal and two models of experimental constipated mice |
title_sort | laxative effects of salecan on normal and two models of experimental constipated mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607894/ https://www.ncbi.nlm.nih.gov/pubmed/23514598 http://dx.doi.org/10.1186/1471-230X-13-52 |
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