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Laxative effects of Salecan on normal and two models of experimental constipated mice

BACKGROUND: Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intest...

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Autores principales: Zhou, Mengyi, Jia, Ping, Chen, Jinping, Xiu, Aihui, Zhao, Yue, Zhan, Yibei, Chen, Peng, Zhang, Jianfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607894/
https://www.ncbi.nlm.nih.gov/pubmed/23514598
http://dx.doi.org/10.1186/1471-230X-13-52
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author Zhou, Mengyi
Jia, Ping
Chen, Jinping
Xiu, Aihui
Zhao, Yue
Zhan, Yibei
Chen, Peng
Zhang, Jianfa
author_facet Zhou, Mengyi
Jia, Ping
Chen, Jinping
Xiu, Aihui
Zhao, Yue
Zhan, Yibei
Chen, Peng
Zhang, Jianfa
author_sort Zhou, Mengyi
collection PubMed
description BACKGROUND: Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intestinal transit in normal and two models of drug-induced constipation mice. METHODS: ICR mice were administrated intragastrically (i.g.) by gavage with 100, 200 and 300 mg/kg body weight (BW) of Salecan while the control mice were received saline. The constipated mice were induced by two types of drugs, loperamide (5 mg/kg BW, i.g.) and clonidine (200 μg/kg BW, i.g.), after Salecan treatment while the control mice were received saline. Number, weight and water content of feces were subsequently measured. Small intestinal transit was monitored by phenol red marker meal. RESULTS: Salecan (300 mg/kg BW) significantly increased the number and weight of feces in normal mice. In two models of drug-induced constipation, Salecan dose-dependently restored the fecal number and fecal weight. The water content of feces was markedly affected by loperamide, but not by clonidine. Treatment with Salecan significantly raised the fecal water content in loperamide-induced constipation mice. Moreover, Salecan markedly stimulated the small intestinal transit in both loperamide- and clonidine-induced constipation model mice. CONCLUSIONS: These results suggest that Salecan has a potential to be used as a hydrophilic laxative for constipation.
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spelling pubmed-36078942013-03-27 Laxative effects of Salecan on normal and two models of experimental constipated mice Zhou, Mengyi Jia, Ping Chen, Jinping Xiu, Aihui Zhao, Yue Zhan, Yibei Chen, Peng Zhang, Jianfa BMC Gastroenterol Research Article BACKGROUND: Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intestinal transit in normal and two models of drug-induced constipation mice. METHODS: ICR mice were administrated intragastrically (i.g.) by gavage with 100, 200 and 300 mg/kg body weight (BW) of Salecan while the control mice were received saline. The constipated mice were induced by two types of drugs, loperamide (5 mg/kg BW, i.g.) and clonidine (200 μg/kg BW, i.g.), after Salecan treatment while the control mice were received saline. Number, weight and water content of feces were subsequently measured. Small intestinal transit was monitored by phenol red marker meal. RESULTS: Salecan (300 mg/kg BW) significantly increased the number and weight of feces in normal mice. In two models of drug-induced constipation, Salecan dose-dependently restored the fecal number and fecal weight. The water content of feces was markedly affected by loperamide, but not by clonidine. Treatment with Salecan significantly raised the fecal water content in loperamide-induced constipation mice. Moreover, Salecan markedly stimulated the small intestinal transit in both loperamide- and clonidine-induced constipation model mice. CONCLUSIONS: These results suggest that Salecan has a potential to be used as a hydrophilic laxative for constipation. BioMed Central 2013-03-20 /pmc/articles/PMC3607894/ /pubmed/23514598 http://dx.doi.org/10.1186/1471-230X-13-52 Text en Copyright ©2013 Zhou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Mengyi
Jia, Ping
Chen, Jinping
Xiu, Aihui
Zhao, Yue
Zhan, Yibei
Chen, Peng
Zhang, Jianfa
Laxative effects of Salecan on normal and two models of experimental constipated mice
title Laxative effects of Salecan on normal and two models of experimental constipated mice
title_full Laxative effects of Salecan on normal and two models of experimental constipated mice
title_fullStr Laxative effects of Salecan on normal and two models of experimental constipated mice
title_full_unstemmed Laxative effects of Salecan on normal and two models of experimental constipated mice
title_short Laxative effects of Salecan on normal and two models of experimental constipated mice
title_sort laxative effects of salecan on normal and two models of experimental constipated mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607894/
https://www.ncbi.nlm.nih.gov/pubmed/23514598
http://dx.doi.org/10.1186/1471-230X-13-52
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