Cargando…

A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats

BACKGROUND: Bartonella henselae is transmitted amongst cats by Ctenocephalides felis and is associated with multiple clinical syndromes in cats and people. In a previous study, monthly spot-on administration of 10% imidacloprid/1% moxidectin was shown to block transmission of B. henselae amongst cat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lappin, Michael R, Davis, Wendell L, Hawley, Jennifer R, Brewer, Melissa, Morris, Arianne, Stanneck, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607996/
https://www.ncbi.nlm.nih.gov/pubmed/23351927
http://dx.doi.org/10.1186/1756-3305-6-26
_version_ 1782264174075707392
author Lappin, Michael R
Davis, Wendell L
Hawley, Jennifer R
Brewer, Melissa
Morris, Arianne
Stanneck, Dorothee
author_facet Lappin, Michael R
Davis, Wendell L
Hawley, Jennifer R
Brewer, Melissa
Morris, Arianne
Stanneck, Dorothee
author_sort Lappin, Michael R
collection PubMed
description BACKGROUND: Bartonella henselae is transmitted amongst cats by Ctenocephalides felis and is associated with multiple clinical syndromes in cats and people. In a previous study, monthly spot-on administration of 10% imidacloprid/1% moxidectin was shown to block transmission of B. henselae amongst cats experimentally exposed to infected C. felis. The purpose of this study was to determine whether application of a flea and tick collar containing 10% imidacloprid and 4.5% flumethrin would lessen C. felis transmission of B. henselae amongst cats for 8 months. METHODS: Specific pathogen free cats (n = 19) were housed in three adjoining enclosures that were separated by mesh to allow C. felis to pass among groups but prevent cats in different enclosures from contacting one another. One group of 4 cats was inoculated intravenously with B. henselae and after infection was confirmed in all cats based on positive PCR assay results, the cats were housed in the middle enclosure. The B. henselae infected cat group was flanked by a group of 8 cats that had the collar placed and maintained for the duration of the study and a group of 7 cats that were not treated. Ctenocephalides felis (50 males and 50 females) raised in an insectary were placed on each of the 4 cats in the B. henselae infected group monthly for 7 applications and then every 2 weeks for 4 applications starting the day the collar was applied. Blood was collected from all cats weekly for Bartonella spp. PCR, serology and culture. RESULTS: While side-effects associated with the collars were not noted, persistent fever necessitating enrofloxacin therapy occurred in two of the untreated cats. While B. henselae infection was ultimately confirmed in 4 of 7 of the untreated cats, none of the cats with collars became infected (P = 0.026). CONCLUSIONS: In this study design, use of a collar containing 10% imidacloprid and 4.5% flumethrin was well tolerated and prevented C. felis transmission of B. henselae amongst cats for 8 months.
format Online
Article
Text
id pubmed-3607996
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36079962013-03-27 A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats Lappin, Michael R Davis, Wendell L Hawley, Jennifer R Brewer, Melissa Morris, Arianne Stanneck, Dorothee Parasit Vectors Research BACKGROUND: Bartonella henselae is transmitted amongst cats by Ctenocephalides felis and is associated with multiple clinical syndromes in cats and people. In a previous study, monthly spot-on administration of 10% imidacloprid/1% moxidectin was shown to block transmission of B. henselae amongst cats experimentally exposed to infected C. felis. The purpose of this study was to determine whether application of a flea and tick collar containing 10% imidacloprid and 4.5% flumethrin would lessen C. felis transmission of B. henselae amongst cats for 8 months. METHODS: Specific pathogen free cats (n = 19) were housed in three adjoining enclosures that were separated by mesh to allow C. felis to pass among groups but prevent cats in different enclosures from contacting one another. One group of 4 cats was inoculated intravenously with B. henselae and after infection was confirmed in all cats based on positive PCR assay results, the cats were housed in the middle enclosure. The B. henselae infected cat group was flanked by a group of 8 cats that had the collar placed and maintained for the duration of the study and a group of 7 cats that were not treated. Ctenocephalides felis (50 males and 50 females) raised in an insectary were placed on each of the 4 cats in the B. henselae infected group monthly for 7 applications and then every 2 weeks for 4 applications starting the day the collar was applied. Blood was collected from all cats weekly for Bartonella spp. PCR, serology and culture. RESULTS: While side-effects associated with the collars were not noted, persistent fever necessitating enrofloxacin therapy occurred in two of the untreated cats. While B. henselae infection was ultimately confirmed in 4 of 7 of the untreated cats, none of the cats with collars became infected (P = 0.026). CONCLUSIONS: In this study design, use of a collar containing 10% imidacloprid and 4.5% flumethrin was well tolerated and prevented C. felis transmission of B. henselae amongst cats for 8 months. BioMed Central 2013-01-25 /pmc/articles/PMC3607996/ /pubmed/23351927 http://dx.doi.org/10.1186/1756-3305-6-26 Text en Copyright ©2013 Lappin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Lappin, Michael R
Davis, Wendell L
Hawley, Jennifer R
Brewer, Melissa
Morris, Arianne
Stanneck, Dorothee
A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats
title A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats
title_full A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats
title_fullStr A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats
title_full_unstemmed A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats
title_short A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats
title_sort flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of bartonella henselae in cats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607996/
https://www.ncbi.nlm.nih.gov/pubmed/23351927
http://dx.doi.org/10.1186/1756-3305-6-26
work_keys_str_mv AT lappinmichaelr afleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT daviswendelll afleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT hawleyjenniferr afleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT brewermelissa afleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT morrisarianne afleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT stanneckdorothee afleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT lappinmichaelr fleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT daviswendelll fleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT hawleyjenniferr fleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT brewermelissa fleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT morrisarianne fleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats
AT stanneckdorothee fleaandtickcollarcontaining10imidaclopridand45flumethrinpreventsfleatransmissionofbartonellahenselaeincats