Cargando…

A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX

BACKGROUND: Genome-wide association studies (GWAS) identify regions of the genome that are associated with particular traits, but do not typically identify specific causative genetic elements. For example, while a large number of single nucleotide polymorphisms associated with type 2 diabetes (T2D)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pendse, Jay, Ramachandran, Prasanna V, Na, Jianbo, Narisu, Narisu, Fink, Jill L, Cagan, Ross L, Collins, Francis S, Baranski, Thomas J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608171/ https://www.ncbi.nlm.nih.gov/pubmed/23445342 http://dx.doi.org/10.1186/1471-2164-14-136

Ejemplares similares

A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy
por: Na, Jianbo, et al.
Publicado: (2013)

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila
por: Musselman, Laura Palanker, et al.
Publicado: (2011)

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits
por: Hudaiberdiev, Sanjarbek, et al.
Publicado: (2023)

A Drosophila model linking diet-induced metabolic disease and cancer
por: Hirabayashi, Susumu, et al.
Publicado: (2014)

Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
por: Gaulton, Kyle J., et al.
Publicado: (2008)

Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis
por: Taylor, Henry J., et al.
Publicado: (2023)

Use of microarray hybrid capture and next-generation sequencing to identify the anatomy of a transgene
por: DuBose, Amanda J., et al.
Publicado: (2013)

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts
por: Narisu, Narisu, et al.
Publicado: (2019)

Similar effects of high-fructose and high-glucose feeding in a Drosophila model of obesity and diabetes
por: Musselman, Laura Palanker, et al.
Publicado: (2019)

Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hours
por: Grenko, Caleb M., et al.
Publicado: (2023)

Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures
por: Rai, Vivek, et al.
Publicado: (2019)

Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis
por: Liu, Shiguo, et al.
Publicado: (2016)

Essential factors involved in the precise targeting and insertion of telomere-specific non-LTR retrotransposon, SART1Bm
por: Nichuguti, Narisu, et al.
Publicado: (2020)

Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs
por: Ruiz-Estevez, M., et al.
Publicado: (2021)

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice
por: Ferreira, Mark J., et al.
Publicado: (2015)

HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs
por: Li, Lingfang, et al.
Publicado: (2016)

A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures
por: Varshney, Arushi, et al.
Publicado: (2021)

A rare novel mutation in TECTA causes autosomal dominant nonsyndromic hearing loss in a Mongolian family
por: Bai, Haihua, et al.
Publicado: (2014)

Identification of COL1A1 associated with immune infiltration in brain lower grade glioma
por: Ren, Junyu, et al.
Publicado: (2022)

Bone dysplasia in Hutchinson‐Gilford progeria syndrome is associated with dysregulated differentiation and function of bone cell populations
por: Cabral, Wayne A., et al.
Publicado: (2023)

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle
por: Taylor, D. Leland, et al.
Publicado: (2019)

HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin
por: Watanabe, Hitoshi, et al.
Publicado: (2014)

The diabetes gene Hhex maintains δ-cell differentiation and islet function
por: Zhang, Jia, et al.
Publicado: (2014)

Novel Haplotype in the HHEX Gene Promoter Associated with Body Length in Pigs
por: Luo, Yabiao, et al.
Publicado: (2023)

A Quantitative Method to Analyze Drosophila Pupal Eye Patterning
por: Johnson, Ruth I., et al.
Publicado: (2009)

Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila
por: Hirabayashi, Susumu, et al.
Publicado: (2015)

Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth
por: Kershaw, R M, et al.
Publicado: (2017)

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation
por: Bonnycastle, Lori L., et al.
Publicado: (2013)

Clinicopathological Significances of Cancer Stem Cell-Associated HHEX Expression in Breast Cancer
por: Zhang, Kexin, et al.
Publicado: (2020)

Unraveling the Influence of HHEX Risk Polymorphism rs7923837 on Multiple Sclerosis Pathogenesis
por: González-Jiménez, Adela, et al.
Publicado: (2022)

Booster or Killer? Research on Undertaking Transferred Industries and Residents’ Well-Being Improvements
por: Ding, Xuhui, et al.
Publicado: (2022)

Putative Prostate Cancer Risk SNP in an Androgen Receptor‐Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites
por: Bu, Huajie, et al.
Publicado: (2015)

Hhex Is Necessary for the Hepatic Differentiation of Mouse ES Cells and Acts via Vegf Signaling
por: Arterbery, Adam S., et al.
Publicado: (2016)

Sequence-specific retrotransposition of 28S rDNA-specific LINE R2Ol in human cells
por: Su, Yuting, et al.
Publicado: (2019)

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
por: Gauvrit, Sébastien, et al.
Publicado: (2018)

Rapid structural regulation, apatite-inducing mechanism and in vivo investigation of microwave-assisted hydrothermally treated titania coating
por: Chen, Lin, et al.
Publicado: (2021)

Niobium carbide–mediated photothermal therapy for infected wound treatment
por: Ren, Junyu, et al.
Publicado: (2022)

Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster
por: Carreira, Valeria Paula, et al.
Publicado: (2016)

The Proline Rich Homeodomain Protein PRH/Hhex Forms Stable Oligomers That Are Highly Resistant to Denaturation
por: Shukla, Anshuman, et al.
Publicado: (2012)

The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development
por: Laidlaw, Brian J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f5b74avp071e5l8rqcvg2fglfh