Cargando…

A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma

Background. Patients with recurrent synovial sarcomas have few options for systemic therapy. Since they express large amounts of endogenous CT (cancer testis) antigens such as NY-ESO-1, we investigated the clinical activity of single agent anti-CTLA4 antibody ipilimumab in patients with advanced or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maki, Robert G., Jungbluth, Achim A., Gnjatic, Sacha, Schwartz, Gary K., D'Adamo, David R., Keohan, Mary Louise, Wagner, Michael J., Scheu, Kelly, Chiu, Rita, Ritter, Erika, Kachel, Jennifer, Lowy, Israel, Old, Lloyd J., Ritter, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608267/ https://www.ncbi.nlm.nih.gov/pubmed/23554566 http://dx.doi.org/10.1155/2013/168145

Ejemplares similares

Split T Cell Tolerance against a Self/Tumor Antigen: Spontaneous CD4(+) but Not CD8(+) T Cell Responses against p53 in Cancer Patients and Healthy Donors
por: Tsuji, Takemasa, et al.
Publicado: (2011)

A Retrospective Analysis of Vinorelbine Chemotherapy for Patients With Previously Treated Soft-Tissue Sarcomas
por: Anderson, Sibyl E., et al.
Publicado: (2006)

An open-label, multiple ascending dose study of the anti-CTLA-4 antibody ipilimumab in viremic HIV patients
por: Colston, Elizabeth, et al.
Publicado: (2018)

Identification of Ny-Eso-1 Epitopes Presented by Human Histocompatibility Antigen (Hla)-Drb4*0101–0103 and Recognized by Cd4(+)T Lymphocytes of Patients with Ny-Eso-1–Expressing Melanoma
por: Jäger, Elke, et al.
Publicado: (2000)

CTLA-4 blockade with ipilimumab: biology, safety, efficacy, and future considerations
por: Camacho, Luis H
Publicado: (2015)

Adverse Events Following Administration of Anti-CTLA4 Antibody Ipilimumab
por: Karimi, Amirali, et al.
Publicado: (2021)

Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies
por: He, Mengnan, et al.
Publicado: (2017)

Phase II Trial of Gemcitabine and Docetaxel with Bevacizumab in Soft Tissue Sarcoma
por: Dickson, Mark A., et al.
Publicado: (2015)

CTLA-4 antibody ipilimumab negatively affects CD4(+) T-cell responses in vitro
por: Rosskopf, Sandra, et al.
Publicado: (2019)

CTLA4 promoter methylation predicts response and progression-free survival in stage IV melanoma treated with anti-CTLA-4 immunotherapy (ipilimumab)
por: Fietz, Simon, et al.
Publicado: (2020)

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase
por: Kelly, M P, et al.
Publicado: (2012)

Clinical Benefit from Ipilimumab Therapy in Melanoma Patients may be Associated with Serum CTLA4 Levels
por: Leung, Anna M., et al.
Publicado: (2014)

Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis
por: Venditti, Olga, et al.
Publicado: (2015)

GI Synovial Sarcomas
por: Sinniah, Rajeev Palar, et al.
Publicado: (2012)

Synovial sarcoma of the mandible
por: Khalili, Maryam, et al.
Publicado: (2012)

Pulmonary synovial sarcoma
por: Gupta, Ankit, et al.
Publicado: (2018)

Synovial Sarcoma of the Hand
por: Ohan, Hovsep, et al.
Publicado: (2020)

Synovial-cell sarcoma
por: Nugud, Ahmed, et al.
Publicado: (2019)

Primary Cutaneous Synovial Sarcoma: An Extremely Rare Report of Superficial Synovial Sarcoma
por: Namazi, Nastaran, et al.
Publicado: (2016)

Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy: The Underlying Mechanisms and Clinical Management
por: Tarhini, Ahmad
Publicado: (2013)

Short communication: A33scFv–cytosine deaminase: a recombinant protein construct for antibody-directed enzyme-prodrug therapy
por: Deckert, P M, et al.
Publicado: (2003)

First-in-Human Treatment With a Dendritic Cell-targeting Lentiviral Vector-expressing NY-ESO-1, LV305, Induces Deep, Durable Response in Refractory Metastatic Synovial Sarcoma Patient
por: Pollack, Seth M., et al.
Publicado: (2017)

Synovial Sarcoma of the Abdominal Wall
por: Hale, J. E., et al.
Publicado: (1970)

Primary Mediastinal Synovial Sarcoma
por: Jeganathan, Reubendra, et al.
Publicado: (2007)

Primary renal synovial sarcoma
por: Grampurohit, Vandana U., et al.
Publicado: (2011)

Primary Renal Synovial Sarcoma
por: Gulum, Mehmet, et al.
Publicado: (2011)

Synovial Sarcoma of the Thyroid Gland
por: Ryu, Chang Hwan, et al.
Publicado: (2011)

Primary Synovial Sarcoma of the Kidney
por: Kawahara, Takashi, et al.
Publicado: (2009)

Primary renal synovial sarcoma
por: Bakhshi, Girish D., et al.
Publicado: (2012)

Primary synovial sarcoma of lung
por: Devleena,, et al.
Publicado: (2014)

Primary Synovial Sarcoma of Lung
por: Cabuk, Devrim, et al.
Publicado: (2014)

Primary Intracranial Synovial Sarcoma
por: Patel, Mohit, et al.
Publicado: (2016)

Synovial Sarcoma of the Abdominal Wall
por: McNeill, Jeanine, et al.
Publicado: (2015)

Primary Synovial Sarcoma of the Lung
por: Boulter, Daniel J., et al.
Publicado: (2015)

Metastatic biomarkers in synovial sarcoma
por: de Necochea-Campion, Rosalia, et al.
Publicado: (2017)

Primary Synovial Sarcoma of the Orbit
por: Xu, Pei, et al.
Publicado: (2017)

Synovial Sarcoma of Ethmoidal Sinus
por: Dhiman, Sapna, et al.
Publicado: (2021)

Primary mediastinal synovial sarcomas
por: Syred, Katherine, et al.
Publicado: (2020)

Primary pulmonary synovial sarcoma
por: Wang, Weixi, et al.
Publicado: (2022)

2081: Phenotypic characterization of the CD4+ T-cell response during anti-CTLA4 therapy with ipilimumab in melanoma patients
por: Sherani, Farha, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8fgrue35qb1sd9pario5cgou30