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Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis

Diagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain rea...

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Autores principales: Manenti, Guglielmo, Altobelli, Simone, Nezzo, Marco, Antonicoli, Marco, Vasili, Erald, Neroni, Luca, Floris, Roberto, Simonetti, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608276/
https://www.ncbi.nlm.nih.gov/pubmed/23555065
http://dx.doi.org/10.1155/2013/415873
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author Manenti, Guglielmo
Altobelli, Simone
Nezzo, Marco
Antonicoli, Marco
Vasili, Erald
Neroni, Luca
Floris, Roberto
Simonetti, Giovanni
author_facet Manenti, Guglielmo
Altobelli, Simone
Nezzo, Marco
Antonicoli, Marco
Vasili, Erald
Neroni, Luca
Floris, Roberto
Simonetti, Giovanni
author_sort Manenti, Guglielmo
collection PubMed
description Diagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain reaction. The role of magnetic resonance imaging specifically in natalizumab-associated progressive multifocal leukoencephalopathy is strengthening, and it is gaining importance not only as an irreplaceable diagnostic tool but also as a surveillance and risk stratifying tool in treated patients. While other imaging techniques such as computed tomography lack sensitivity and specificity, magnetic resonance performed with morphological and functional sequences offers clinicians the possibility to early identify the stage of the disease and the emergence of an immune reconstitution inflammatory syndrome after natalizumab blood removal plasmapheresis.
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spelling pubmed-36082762013-04-02 Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis Manenti, Guglielmo Altobelli, Simone Nezzo, Marco Antonicoli, Marco Vasili, Erald Neroni, Luca Floris, Roberto Simonetti, Giovanni Case Rep Radiol Case Report Diagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain reaction. The role of magnetic resonance imaging specifically in natalizumab-associated progressive multifocal leukoencephalopathy is strengthening, and it is gaining importance not only as an irreplaceable diagnostic tool but also as a surveillance and risk stratifying tool in treated patients. While other imaging techniques such as computed tomography lack sensitivity and specificity, magnetic resonance performed with morphological and functional sequences offers clinicians the possibility to early identify the stage of the disease and the emergence of an immune reconstitution inflammatory syndrome after natalizumab blood removal plasmapheresis. Hindawi Publishing Corporation 2013 2013-03-10 /pmc/articles/PMC3608276/ /pubmed/23555065 http://dx.doi.org/10.1155/2013/415873 Text en Copyright © 2013 Guglielmo Manenti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Manenti, Guglielmo
Altobelli, Simone
Nezzo, Marco
Antonicoli, Marco
Vasili, Erald
Neroni, Luca
Floris, Roberto
Simonetti, Giovanni
Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis
title Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis
title_full Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis
title_fullStr Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis
title_full_unstemmed Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis
title_short Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis
title_sort early magnetic resonance detection of natalizumab-related progressive multifocal leukoencephalopathy in a patient with multiple sclerosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608276/
https://www.ncbi.nlm.nih.gov/pubmed/23555065
http://dx.doi.org/10.1155/2013/415873
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