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Peritoneal mast cell stabilization potential of Pothos scandens L
OBJECTIVE: To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts MATERIALS AND METHODS: Pothos scandens L. (family- Araceae) aerial part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of P. scandens were evaluate...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608302/ https://www.ncbi.nlm.nih.gov/pubmed/23542883 http://dx.doi.org/10.4103/0253-7613.106442 |
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author | Gupta, Saurabh Duraiswamy, B. Satishkumar, M. N. |
author_facet | Gupta, Saurabh Duraiswamy, B. Satishkumar, M. N. |
author_sort | Gupta, Saurabh |
collection | PubMed |
description | OBJECTIVE: To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts MATERIALS AND METHODS: Pothos scandens L. (family- Araceae) aerial part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of P. scandens were evaluated for stabilization of mast cell in rat allergic models. The extract of P. scandens ethanolic, 50% aqueous ethanolic and aqueous (1, 10 and 100 μg/ml) was studied for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80. RESULT: Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic, 50% aqueous ethanolic and aqueous extracts of P. scandens L. showed dose dependent increase in the number of intact cells when compare with C48/80 at the concentration of 10 and 100 μg/ml. It virtues further work towards the isolation of phytoconstituents from this plant. CONCLUSION: This finding provides evidence that the P. scandens L. inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. P. scandens has a potential as allergic anti- asthmatic agent. |
format | Online Article Text |
id | pubmed-3608302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36083022013-03-29 Peritoneal mast cell stabilization potential of Pothos scandens L Gupta, Saurabh Duraiswamy, B. Satishkumar, M. N. Indian J Pharmacol Short Communication OBJECTIVE: To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts MATERIALS AND METHODS: Pothos scandens L. (family- Araceae) aerial part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of P. scandens were evaluated for stabilization of mast cell in rat allergic models. The extract of P. scandens ethanolic, 50% aqueous ethanolic and aqueous (1, 10 and 100 μg/ml) was studied for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80. RESULT: Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic, 50% aqueous ethanolic and aqueous extracts of P. scandens L. showed dose dependent increase in the number of intact cells when compare with C48/80 at the concentration of 10 and 100 μg/ml. It virtues further work towards the isolation of phytoconstituents from this plant. CONCLUSION: This finding provides evidence that the P. scandens L. inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. P. scandens has a potential as allergic anti- asthmatic agent. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3608302/ /pubmed/23542883 http://dx.doi.org/10.4103/0253-7613.106442 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Gupta, Saurabh Duraiswamy, B. Satishkumar, M. N. Peritoneal mast cell stabilization potential of Pothos scandens L |
title | Peritoneal mast cell stabilization potential of Pothos scandens L |
title_full | Peritoneal mast cell stabilization potential of Pothos scandens L |
title_fullStr | Peritoneal mast cell stabilization potential of Pothos scandens L |
title_full_unstemmed | Peritoneal mast cell stabilization potential of Pothos scandens L |
title_short | Peritoneal mast cell stabilization potential of Pothos scandens L |
title_sort | peritoneal mast cell stabilization potential of pothos scandens l |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608302/ https://www.ncbi.nlm.nih.gov/pubmed/23542883 http://dx.doi.org/10.4103/0253-7613.106442 |
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