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Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair

Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage...

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Detalles Bibliográficos
Autores principales: Li, Ming, Ikehara, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608346/
https://www.ncbi.nlm.nih.gov/pubmed/23554816
http://dx.doi.org/10.1155/2013/132642
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author Li, Ming
Ikehara, Susumu
author_facet Li, Ming
Ikehara, Susumu
author_sort Li, Ming
collection PubMed
description Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair.
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spelling pubmed-36083462013-04-02 Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair Li, Ming Ikehara, Susumu Stem Cells Int Review Article Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair. Hindawi Publishing Corporation 2013 2013-03-11 /pmc/articles/PMC3608346/ /pubmed/23554816 http://dx.doi.org/10.1155/2013/132642 Text en Copyright © 2013 M. Li and S. Ikehara. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Ming
Ikehara, Susumu
Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
title Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
title_full Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
title_fullStr Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
title_full_unstemmed Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
title_short Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
title_sort bone-marrow-derived mesenchymal stem cells for organ repair
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608346/
https://www.ncbi.nlm.nih.gov/pubmed/23554816
http://dx.doi.org/10.1155/2013/132642
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