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Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608346/ https://www.ncbi.nlm.nih.gov/pubmed/23554816 http://dx.doi.org/10.1155/2013/132642 |
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author | Li, Ming Ikehara, Susumu |
author_facet | Li, Ming Ikehara, Susumu |
author_sort | Li, Ming |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair. |
format | Online Article Text |
id | pubmed-3608346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36083462013-04-02 Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair Li, Ming Ikehara, Susumu Stem Cells Int Review Article Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair. Hindawi Publishing Corporation 2013 2013-03-11 /pmc/articles/PMC3608346/ /pubmed/23554816 http://dx.doi.org/10.1155/2013/132642 Text en Copyright © 2013 M. Li and S. Ikehara. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Li, Ming Ikehara, Susumu Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
title | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
title_full | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
title_fullStr | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
title_full_unstemmed | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
title_short | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
title_sort | bone-marrow-derived mesenchymal stem cells for organ repair |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608346/ https://www.ncbi.nlm.nih.gov/pubmed/23554816 http://dx.doi.org/10.1155/2013/132642 |
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