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N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates

Two conserved ubiquitin ligases, Hrd1 and Doa10, mediate most endoplasmic reticulum–associated protein degradation (ERAD) in yeast. Degradation signals (degrons) recognized by these ubiquitin ligases remain poorly characterized. Doa10 recognizes the Deg1 degron from the MATα2 transcription factor. W...

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Detalles Bibliográficos
Autores principales:	Zattas, Dimitrios, Adle, David J., Rubenstein, Eric M., Hochstrasser, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608499/ https://www.ncbi.nlm.nih.gov/pubmed/23363603 http://dx.doi.org/10.1091/mbc.E12-11-0838

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