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Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics
A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-phosphonic acid dimethyl ester (1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (1b) and 1-benzothiazol-2-yl-5-(2-hydroxyph...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608880/ https://www.ncbi.nlm.nih.gov/pubmed/23542890 http://dx.doi.org/10.1007/s00044-012-0233-5 |
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author | Kupcewicz, Bogumiła Sobiesiak, Krzysztof Malinowska, Katarzyna Koprowska, Kamila Czyz, Malgorzata Keppler, Bernhard Budzisz, Elżbieta |
author_facet | Kupcewicz, Bogumiła Sobiesiak, Krzysztof Malinowska, Katarzyna Koprowska, Kamila Czyz, Malgorzata Keppler, Bernhard Budzisz, Elżbieta |
author_sort | Kupcewicz, Bogumiła |
collection | PubMed |
description | A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-phosphonic acid dimethyl ester (1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (1b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1c) were characterized regarding to electrochemical and antioxidant properties. All complexes exhibit suitable Cu(II)/Cu(I) redox potential (E (1/2)) to act as antioxidant enzymes mimic. The five of these complexes were found to be trifunctional enzyme mimics possessing SOD, CAT and GPx-like catalytic activities. Moreover, Cu(II) complexes were capable to decrease ROS level in melanoma cells and observed effects were not merely a reflection of cytotoxicity. |
format | Online Article Text |
id | pubmed-3608880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-36088802013-03-28 Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics Kupcewicz, Bogumiła Sobiesiak, Krzysztof Malinowska, Katarzyna Koprowska, Kamila Czyz, Malgorzata Keppler, Bernhard Budzisz, Elżbieta Med Chem Res Original Research A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-phosphonic acid dimethyl ester (1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (1b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1c) were characterized regarding to electrochemical and antioxidant properties. All complexes exhibit suitable Cu(II)/Cu(I) redox potential (E (1/2)) to act as antioxidant enzymes mimic. The five of these complexes were found to be trifunctional enzyme mimics possessing SOD, CAT and GPx-like catalytic activities. Moreover, Cu(II) complexes were capable to decrease ROS level in melanoma cells and observed effects were not merely a reflection of cytotoxicity. Springer-Verlag 2012-09-26 2013 /pmc/articles/PMC3608880/ /pubmed/23542890 http://dx.doi.org/10.1007/s00044-012-0233-5 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Research Kupcewicz, Bogumiła Sobiesiak, Krzysztof Malinowska, Katarzyna Koprowska, Kamila Czyz, Malgorzata Keppler, Bernhard Budzisz, Elżbieta Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics |
title | Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics |
title_full | Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics |
title_fullStr | Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics |
title_full_unstemmed | Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics |
title_short | Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics |
title_sort | copper(ii) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608880/ https://www.ncbi.nlm.nih.gov/pubmed/23542890 http://dx.doi.org/10.1007/s00044-012-0233-5 |
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