Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity

BACKGROUND: Adenosine triphosphate (ATP) is secreted from hepatocytes under physiological conditions and plays an important role in liver biology through the activation of P2 receptors. Conversely, higher extracellular ATP concentrations, as observed during necrosis, trigger inflammatory responses t...

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Detalles Bibliográficos
Autores principales: Amaral, Sylvia S, Oliveira, André G, Marques, Pedro E, Quintão, Jayane L D, Pires, Daniele A, Resende, Rodrigo R, Sousa, Bruna R, Melgaço, Juliana G, Pinto, Marcelo A, Russo, Remo C, Gomes, Ariane K C, Andrade, Lidia M, Zanin, Rafael F, Pereira, Rafaela V S, Bonorino, Cristina, Soriani, Frederico M, Lima, Cristiano X, Cara, Denise C, Teixeira, Mauro M, Leite, Maria F, Menezes, Gustavo B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608937/
https://www.ncbi.nlm.nih.gov/pubmed/23384127
http://dx.doi.org/10.1186/1478-811X-11-10

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