Cargando…
Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum
Studies of patterned spontaneous activity can elucidate how the organization of neural circuits emerges. Using in vivo two-photon Ca(2+) imaging, we studied spatio-temporal patterns of spontaneous activity in the optic tectum of Xenopus tadpoles. We found rhythmic patterns of global synchronous spon...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609019/ https://www.ncbi.nlm.nih.gov/pubmed/23531884 http://dx.doi.org/10.1038/srep01552 |
_version_ | 1782264304411607040 |
---|---|
author | Imaizumi, Kazuo Shih, Jonathan Y. Farris, Hamilton E. |
author_facet | Imaizumi, Kazuo Shih, Jonathan Y. Farris, Hamilton E. |
author_sort | Imaizumi, Kazuo |
collection | PubMed |
description | Studies of patterned spontaneous activity can elucidate how the organization of neural circuits emerges. Using in vivo two-photon Ca(2+) imaging, we studied spatio-temporal patterns of spontaneous activity in the optic tectum of Xenopus tadpoles. We found rhythmic patterns of global synchronous spontaneous activity between neurons, which depends on visual experience and developmental stage. By contrast, synchronous spontaneous activity between non-neuronal cells is mediated more locally. To understand the source of the neuronal spontaneous activity, input to the tectum was systematically removed. Whereas removing input from the visual or mechanosensory system alone had little effect on patterned spontaneous activity, removing input from both systems drastically altered it. These results suggest that either input is sufficient to maintain the intrinsically generated spontaneous activity and that patterned spontaneous activity results from input from multisensory systems. Thus, the amphibian midbrain differs from the mammalian visual system, whose spontaneous activity is controlled by retinal waves. |
format | Online Article Text |
id | pubmed-3609019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36090192013-04-04 Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum Imaizumi, Kazuo Shih, Jonathan Y. Farris, Hamilton E. Sci Rep Article Studies of patterned spontaneous activity can elucidate how the organization of neural circuits emerges. Using in vivo two-photon Ca(2+) imaging, we studied spatio-temporal patterns of spontaneous activity in the optic tectum of Xenopus tadpoles. We found rhythmic patterns of global synchronous spontaneous activity between neurons, which depends on visual experience and developmental stage. By contrast, synchronous spontaneous activity between non-neuronal cells is mediated more locally. To understand the source of the neuronal spontaneous activity, input to the tectum was systematically removed. Whereas removing input from the visual or mechanosensory system alone had little effect on patterned spontaneous activity, removing input from both systems drastically altered it. These results suggest that either input is sufficient to maintain the intrinsically generated spontaneous activity and that patterned spontaneous activity results from input from multisensory systems. Thus, the amphibian midbrain differs from the mammalian visual system, whose spontaneous activity is controlled by retinal waves. Nature Publishing Group 2013-03-27 /pmc/articles/PMC3609019/ /pubmed/23531884 http://dx.doi.org/10.1038/srep01552 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Imaizumi, Kazuo Shih, Jonathan Y. Farris, Hamilton E. Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum |
title | Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum |
title_full | Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum |
title_fullStr | Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum |
title_full_unstemmed | Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum |
title_short | Global Hyper-synchronous Spontaneous Activity in the Developing Optic Tectum |
title_sort | global hyper-synchronous spontaneous activity in the developing optic tectum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609019/ https://www.ncbi.nlm.nih.gov/pubmed/23531884 http://dx.doi.org/10.1038/srep01552 |
work_keys_str_mv | AT imaizumikazuo globalhypersynchronousspontaneousactivityinthedevelopingoptictectum AT shihjonathany globalhypersynchronousspontaneousactivityinthedevelopingoptictectum AT farrishamiltone globalhypersynchronousspontaneousactivityinthedevelopingoptictectum |