Class I HDAC Inhibition Blocks Cocaine-Induced Plasticity Through Targeted Changes in Histone Methylation

Induction of histone acetylation in the nucleus accumbens (NAc), a key brain reward region, promotes cocaine-induced alterations in gene expression. Histone deacetylases (HDACs) tightly regulate the acetylation of histone tails, but little is known about the functional specificity of different HDAC...

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Detalles Bibliográficos
Autores principales: Kennedy, Pamela J., Feng, Jian, Robison, A.J., Maze, Ian, Badimon, Ana, Mouzon, Ezekiell, Chaudhury, Dipesh, Damez-Werno, Diane M., Haggarty, Stephen J., Han, Ming-Hu, Bassel-Duby, Rhonda, Olson, Eric N., Nestler, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609040/
https://www.ncbi.nlm.nih.gov/pubmed/23475113
http://dx.doi.org/10.1038/nn.3354

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