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Generation of a novel murine model of Aβ deposition based on the expression of human wild-type amyloid precursor protein gene
Mouse models of Alzheimer disease (AD) have been generated based on Amyloid-β Precursor Protein (AβPP) and the Presenilin (PSEN) gene mutations associated with familial AD (FAD). Such models have provided valuable insights into AD pathogenesis and represent an important research tool for the discove...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609061/ https://www.ncbi.nlm.nih.gov/pubmed/22874668 http://dx.doi.org/10.4161/pri.21023 |