Cargando…
Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis
Adipocytes differentiate and function in environments rich in extracellular matrix (ECM) proteins. The phenotypes of genetically modified mice have aided in recognizing the importance of ECM proteins and their modifiers, e.g., proteinases, in the regulation of obesity and metabolism. Most of the mol...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609086/ https://www.ncbi.nlm.nih.gov/pubmed/23700517 http://dx.doi.org/10.4161/adip.19752 |
_version_ | 1782264309209890816 |
---|---|
author | Chun, Tae-Hwa |
author_facet | Chun, Tae-Hwa |
author_sort | Chun, Tae-Hwa |
collection | PubMed |
description | Adipocytes differentiate and function in environments rich in extracellular matrix (ECM) proteins. The phenotypes of genetically modified mice have aided in recognizing the importance of ECM proteins and their modifiers, e.g., proteinases, in the regulation of obesity and metabolism. Most of the molecular mechanisms through which ECM proteins and modifiers regulate adipogenesis or adipocyte function have not been fully defined. Adipose tissue fibrosis may be a factor that links obesity to diabetes or cardiovascular disease risk in conjunction with tissue inflammation. Defining the molecular mechanisms through which the ECM environment regulates adipogenesis and adipocyte function should provide us with a better understanding of the disease link between obesity and diabetes or cardiovascular diseases. |
format | Online Article Text |
id | pubmed-3609086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36090862013-05-22 Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis Chun, Tae-Hwa Adipocyte Review Adipocytes differentiate and function in environments rich in extracellular matrix (ECM) proteins. The phenotypes of genetically modified mice have aided in recognizing the importance of ECM proteins and their modifiers, e.g., proteinases, in the regulation of obesity and metabolism. Most of the molecular mechanisms through which ECM proteins and modifiers regulate adipogenesis or adipocyte function have not been fully defined. Adipose tissue fibrosis may be a factor that links obesity to diabetes or cardiovascular disease risk in conjunction with tissue inflammation. Defining the molecular mechanisms through which the ECM environment regulates adipogenesis and adipocyte function should provide us with a better understanding of the disease link between obesity and diabetes or cardiovascular diseases. Landes Bioscience 2012-04-01 /pmc/articles/PMC3609086/ /pubmed/23700517 http://dx.doi.org/10.4161/adip.19752 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Chun, Tae-Hwa Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis |
title | Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis |
title_full | Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis |
title_fullStr | Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis |
title_full_unstemmed | Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis |
title_short | Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis |
title_sort | peri-adipocyte ecm remodeling in obesity and adipose tissue fibrosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609086/ https://www.ncbi.nlm.nih.gov/pubmed/23700517 http://dx.doi.org/10.4161/adip.19752 |
work_keys_str_mv | AT chuntaehwa periadipocyteecmremodelinginobesityandadiposetissuefibrosis |