Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance

Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic prote...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Ri-Yao, Havel, Peter J., Liu, Fu-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609087/
https://www.ncbi.nlm.nih.gov/pubmed/23700518
http://dx.doi.org/10.4161/adip.19465
_version_ 1782264309430091776
author Yang, Ri-Yao
Havel, Peter J.
Liu, Fu-Tong
author_facet Yang, Ri-Yao
Havel, Peter J.
Liu, Fu-Tong
author_sort Yang, Ri-Yao
collection PubMed
description Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic protein kinase A (PKA) signaling. Mice deficient in galectin-12 exhibit enhanced adipocyte lipolysis, increased mitochondria respiration, reduced adiposity and ameliorated insulin resistance associated with weight gain. The results suggest that galectin-12 may be a useful target for treatment of obesity-related metabolic conditions, such as insulin resistance, metabolic syndrome, and type 2 diabetes. Most previously described galectins largely reside in the cytosol, although they can also be induced to become associated with membrane-containing structures. Along with an in-depth characterization of galectin-12, this mini-review comments on this first report of a galectin normally localized specifically in an organelle that performs an important intracellular function. Further studies will help shed light on how this protein regulates cellular homeostasis, especially energy homeostasis, and provide additional insight into the intracellular functions of galectins.
format Online
Article
Text
id pubmed-3609087
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36090872013-05-22 Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance Yang, Ri-Yao Havel, Peter J. Liu, Fu-Tong Adipocyte Mini Review Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic protein kinase A (PKA) signaling. Mice deficient in galectin-12 exhibit enhanced adipocyte lipolysis, increased mitochondria respiration, reduced adiposity and ameliorated insulin resistance associated with weight gain. The results suggest that galectin-12 may be a useful target for treatment of obesity-related metabolic conditions, such as insulin resistance, metabolic syndrome, and type 2 diabetes. Most previously described galectins largely reside in the cytosol, although they can also be induced to become associated with membrane-containing structures. Along with an in-depth characterization of galectin-12, this mini-review comments on this first report of a galectin normally localized specifically in an organelle that performs an important intracellular function. Further studies will help shed light on how this protein regulates cellular homeostasis, especially energy homeostasis, and provide additional insight into the intracellular functions of galectins. Landes Bioscience 2012-04-01 /pmc/articles/PMC3609087/ /pubmed/23700518 http://dx.doi.org/10.4161/adip.19465 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Mini Review
Yang, Ri-Yao
Havel, Peter J.
Liu, Fu-Tong
Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance
title Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance
title_full Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance
title_fullStr Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance
title_full_unstemmed Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance
title_short Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance
title_sort galectin-12: a protein associated with lipid droplets that regulates lipid metabolism and energy balance
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609087/
https://www.ncbi.nlm.nih.gov/pubmed/23700518
http://dx.doi.org/10.4161/adip.19465
work_keys_str_mv AT yangriyao galectin12aproteinassociatedwithlipiddropletsthatregulateslipidmetabolismandenergybalance
AT havelpeterj galectin12aproteinassociatedwithlipiddropletsthatregulateslipidmetabolismandenergybalance
AT liufutong galectin12aproteinassociatedwithlipiddropletsthatregulateslipidmetabolismandenergybalance