Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance
Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic prote...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609087/ https://www.ncbi.nlm.nih.gov/pubmed/23700518 http://dx.doi.org/10.4161/adip.19465 |
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author | Yang, Ri-Yao Havel, Peter J. Liu, Fu-Tong |
author_facet | Yang, Ri-Yao Havel, Peter J. Liu, Fu-Tong |
author_sort | Yang, Ri-Yao |
collection | PubMed |
description | Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic protein kinase A (PKA) signaling. Mice deficient in galectin-12 exhibit enhanced adipocyte lipolysis, increased mitochondria respiration, reduced adiposity and ameliorated insulin resistance associated with weight gain. The results suggest that galectin-12 may be a useful target for treatment of obesity-related metabolic conditions, such as insulin resistance, metabolic syndrome, and type 2 diabetes. Most previously described galectins largely reside in the cytosol, although they can also be induced to become associated with membrane-containing structures. Along with an in-depth characterization of galectin-12, this mini-review comments on this first report of a galectin normally localized specifically in an organelle that performs an important intracellular function. Further studies will help shed light on how this protein regulates cellular homeostasis, especially energy homeostasis, and provide additional insight into the intracellular functions of galectins. |
format | Online Article Text |
id | pubmed-3609087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36090872013-05-22 Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance Yang, Ri-Yao Havel, Peter J. Liu, Fu-Tong Adipocyte Mini Review Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic protein kinase A (PKA) signaling. Mice deficient in galectin-12 exhibit enhanced adipocyte lipolysis, increased mitochondria respiration, reduced adiposity and ameliorated insulin resistance associated with weight gain. The results suggest that galectin-12 may be a useful target for treatment of obesity-related metabolic conditions, such as insulin resistance, metabolic syndrome, and type 2 diabetes. Most previously described galectins largely reside in the cytosol, although they can also be induced to become associated with membrane-containing structures. Along with an in-depth characterization of galectin-12, this mini-review comments on this first report of a galectin normally localized specifically in an organelle that performs an important intracellular function. Further studies will help shed light on how this protein regulates cellular homeostasis, especially energy homeostasis, and provide additional insight into the intracellular functions of galectins. Landes Bioscience 2012-04-01 /pmc/articles/PMC3609087/ /pubmed/23700518 http://dx.doi.org/10.4161/adip.19465 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Mini Review Yang, Ri-Yao Havel, Peter J. Liu, Fu-Tong Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance |
title | Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance |
title_full | Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance |
title_fullStr | Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance |
title_full_unstemmed | Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance |
title_short | Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance |
title_sort | galectin-12: a protein associated with lipid droplets that regulates lipid metabolism and energy balance |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609087/ https://www.ncbi.nlm.nih.gov/pubmed/23700518 http://dx.doi.org/10.4161/adip.19465 |
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