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Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location

Increased visceral adiposity is a risk factor for metabolic disorders such as dyslipidemia, hypertension, insulin resistance and type 2 diabetes, whereas peripheral (subcutaneous) obesity is not. Though the specific mechanisms which contribute to these adipose depot differences are unknown, visceral...

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Autores principales: Foster, Michelle T., Pagliassotti, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609102/
https://www.ncbi.nlm.nih.gov/pubmed/23700533
http://dx.doi.org/10.4161/adip.21756
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author Foster, Michelle T.
Pagliassotti, Michael J.
author_facet Foster, Michelle T.
Pagliassotti, Michael J.
author_sort Foster, Michelle T.
collection PubMed
description Increased visceral adiposity is a risk factor for metabolic disorders such as dyslipidemia, hypertension, insulin resistance and type 2 diabetes, whereas peripheral (subcutaneous) obesity is not. Though the specific mechanisms which contribute to these adipose depot differences are unknown, visceral fat accumulation is proposed to result in metabolic dysregulation because of increased effluent, e.g., fatty acids and/or adipokines/cytokines, to the liver via the hepatic portal vein. Pathological significance of visceral fat accumulation is also attributed to adipose depot/adipocyte-specific characteristics, specifically differences in structural, physiologic and metabolic characteristics compared with subcutaneous fat. Fat manipulations, such as removal or transplantation, have been utilized to identify location dependent or independent factors that play a role in metabolic dysregulation. Obesity-induced alterations in adipose tissue function/intrinsic characteristics, but not mass, appear to be responsible for obesity-induced metabolic dysregulation, thus “quality” is more important than “quantity.” This review summarizes the implications of obesity-induced metabolic dysfunction as it relates to anatomic site and inherent adipocyte characteristics.
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spelling pubmed-36091022013-05-22 Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location Foster, Michelle T. Pagliassotti, Michael J. Adipocyte Review Increased visceral adiposity is a risk factor for metabolic disorders such as dyslipidemia, hypertension, insulin resistance and type 2 diabetes, whereas peripheral (subcutaneous) obesity is not. Though the specific mechanisms which contribute to these adipose depot differences are unknown, visceral fat accumulation is proposed to result in metabolic dysregulation because of increased effluent, e.g., fatty acids and/or adipokines/cytokines, to the liver via the hepatic portal vein. Pathological significance of visceral fat accumulation is also attributed to adipose depot/adipocyte-specific characteristics, specifically differences in structural, physiologic and metabolic characteristics compared with subcutaneous fat. Fat manipulations, such as removal or transplantation, have been utilized to identify location dependent or independent factors that play a role in metabolic dysregulation. Obesity-induced alterations in adipose tissue function/intrinsic characteristics, but not mass, appear to be responsible for obesity-induced metabolic dysregulation, thus “quality” is more important than “quantity.” This review summarizes the implications of obesity-induced metabolic dysfunction as it relates to anatomic site and inherent adipocyte characteristics. Landes Bioscience 2012-10-01 /pmc/articles/PMC3609102/ /pubmed/23700533 http://dx.doi.org/10.4161/adip.21756 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Foster, Michelle T.
Pagliassotti, Michael J.
Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location
title Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location
title_full Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location
title_fullStr Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location
title_full_unstemmed Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location
title_short Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location
title_sort metabolic alterations following visceral fat removal and expansion: beyond anatomic location
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609102/
https://www.ncbi.nlm.nih.gov/pubmed/23700533
http://dx.doi.org/10.4161/adip.21756
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