Cargando…

A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults

Relative to diets enriched in palmitic acid (PA), diets rich in oleic acid (OA) are associated with reduced risk of type 2 diabetes. To gain insight into mechanisms underlying these observations, we applied comprehensive lipidomic profiling to specimens collected from healthy adults enrolled in a ra...

Descripción completa

Detalles Bibliográficos
Autores principales: Kien, C. Lawrence, Bunn, Janice Y., Poynter, Matthew E., Stevens, Robert, Bain, James, Ikayeva, Olga, Fukagawa, Naomi K., Champagne, Catherine M., Crain, Karen I., Koves, Timothy R., Muoio, Deborah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609566/
https://www.ncbi.nlm.nih.gov/pubmed/23238293
http://dx.doi.org/10.2337/db12-0363
_version_ 1782264334537195520
author Kien, C. Lawrence
Bunn, Janice Y.
Poynter, Matthew E.
Stevens, Robert
Bain, James
Ikayeva, Olga
Fukagawa, Naomi K.
Champagne, Catherine M.
Crain, Karen I.
Koves, Timothy R.
Muoio, Deborah M.
author_facet Kien, C. Lawrence
Bunn, Janice Y.
Poynter, Matthew E.
Stevens, Robert
Bain, James
Ikayeva, Olga
Fukagawa, Naomi K.
Champagne, Catherine M.
Crain, Karen I.
Koves, Timothy R.
Muoio, Deborah M.
author_sort Kien, C. Lawrence
collection PubMed
description Relative to diets enriched in palmitic acid (PA), diets rich in oleic acid (OA) are associated with reduced risk of type 2 diabetes. To gain insight into mechanisms underlying these observations, we applied comprehensive lipidomic profiling to specimens collected from healthy adults enrolled in a randomized, crossover trial comparing a high-PA diet to a low-PA/high-OA (HOA) diet. Effects on insulin sensitivity (S(I)) and disposition index (DI) were assessed by intravenous glucose tolerance testing. In women, but not men, S(I) and DI were higher during HOA. The effect of HOA on S(I) correlated positively with physical fitness upon enrollment. Principal components analysis of either fasted or fed-state metabolites identified one factor affected by diet and heavily weighted by the PA/OA ratio of serum and muscle lipids. In women, this factor correlated inversely with S(I) in the fasted and fed states. Medium-chain acylcarnitines emerged as strong negative correlates of S(I), and the HOA diet was accompanied by lower serum and muscle ceramide concentrations and reductions in molecular biomarkers of inflammatory and oxidative stress. This study provides evidence that the dietary PA/OA ratio impacts diabetes risk in women.
format Online
Article
Text
id pubmed-3609566
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-36095662014-04-01 A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults Kien, C. Lawrence Bunn, Janice Y. Poynter, Matthew E. Stevens, Robert Bain, James Ikayeva, Olga Fukagawa, Naomi K. Champagne, Catherine M. Crain, Karen I. Koves, Timothy R. Muoio, Deborah M. Diabetes Original Research Relative to diets enriched in palmitic acid (PA), diets rich in oleic acid (OA) are associated with reduced risk of type 2 diabetes. To gain insight into mechanisms underlying these observations, we applied comprehensive lipidomic profiling to specimens collected from healthy adults enrolled in a randomized, crossover trial comparing a high-PA diet to a low-PA/high-OA (HOA) diet. Effects on insulin sensitivity (S(I)) and disposition index (DI) were assessed by intravenous glucose tolerance testing. In women, but not men, S(I) and DI were higher during HOA. The effect of HOA on S(I) correlated positively with physical fitness upon enrollment. Principal components analysis of either fasted or fed-state metabolites identified one factor affected by diet and heavily weighted by the PA/OA ratio of serum and muscle lipids. In women, this factor correlated inversely with S(I) in the fasted and fed states. Medium-chain acylcarnitines emerged as strong negative correlates of S(I), and the HOA diet was accompanied by lower serum and muscle ceramide concentrations and reductions in molecular biomarkers of inflammatory and oxidative stress. This study provides evidence that the dietary PA/OA ratio impacts diabetes risk in women. American Diabetes Association 2013-04 2013-03-14 /pmc/articles/PMC3609566/ /pubmed/23238293 http://dx.doi.org/10.2337/db12-0363 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Kien, C. Lawrence
Bunn, Janice Y.
Poynter, Matthew E.
Stevens, Robert
Bain, James
Ikayeva, Olga
Fukagawa, Naomi K.
Champagne, Catherine M.
Crain, Karen I.
Koves, Timothy R.
Muoio, Deborah M.
A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
title A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
title_full A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
title_fullStr A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
title_full_unstemmed A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
title_short A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
title_sort lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609566/
https://www.ncbi.nlm.nih.gov/pubmed/23238293
http://dx.doi.org/10.2337/db12-0363
work_keys_str_mv AT kienclawrence alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT bunnjanicey alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT poyntermatthewe alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT stevensrobert alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT bainjames alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT ikayevaolga alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT fukagawanaomik alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT champagnecatherinem alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT crainkareni alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT kovestimothyr alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT muoiodeborahm alipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT kienclawrence lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT bunnjanicey lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT poyntermatthewe lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT stevensrobert lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT bainjames lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT ikayevaolga lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT fukagawanaomik lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT champagnecatherinem lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT crainkareni lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT kovestimothyr lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults
AT muoiodeborahm lipidomicsanalysisoftherelationshipbetweendietaryfattyacidcompositionandinsulinsensitivityinyoungadults