Dual Inhibition of Classical Protein Kinase C-α and Protein Kinase C-β Isoforms Protects Against Experimental Murine Diabetic Nephropathy

Activation of protein kinase C (PKC) has been implicated in the pathogenesis of diabetic nephropathy with proteinuria and peritubular extracellular matrix production. We have previously shown that the PKC isoforms α and β mediate different cellular effects. PKC-β contributes to hyperglycemia-induced...

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Detalles Bibliográficos
Autores principales: Menne, Jan, Shushakova, Nelli, Bartels, Janina, Kiyan, Yulia, Laudeley, Robert, Haller, Hermann, Park, Joon-Keun, Meier, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609593/
https://www.ncbi.nlm.nih.gov/pubmed/23434935
http://dx.doi.org/10.2337/db12-0534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609593/
https://www.ncbi.nlm.nih.gov/pubmed/23434935
http://dx.doi.org/10.2337/db12-0534

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