Polyanionic Candidate Microbicides Accelerate the Formation of Semen-Derived Amyloid Fibrils to Enhance HIV-1 Infection

Polyanionic candidate microbicides, including cellulose sulfate, carrageenan, PRO 2000, were proven ineffective in preventing HIV-1 transmission and even cellulose sulfate showed increased risk of HIV acquisition in the Phase III efficacy trials. Semen plays critical roles in HIV-1 sexual transmissi...

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Detalles Bibliográficos
Autores principales: Tan, Suiyi, Lu, Lu, Li, Lin, Liu, Jixiang, Oksov, Yelena, Lu, Hong, Jiang, Shibo, Liu, Shuwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609764/
https://www.ncbi.nlm.nih.gov/pubmed/23544097
http://dx.doi.org/10.1371/journal.pone.0059777

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