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Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death
The lipid phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P (2)), synthesised by PIKfyve, regulates a number of intracellular membrane trafficking pathways. Genetic alteration of the PIKfyve complex, leading to even a mild reduction in PtdIns(3,5)P (2), results in marked neurodegeneration via an u...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609765/ https://www.ncbi.nlm.nih.gov/pubmed/23544129 http://dx.doi.org/10.1371/journal.pone.0060152 |